Asa Abeliovich, M.D., Ph.D., P&S 15-405, Ext. 5-1150
The molecular mechanisms of neurodegeneration and the function and survival of dopamine receptors. We are studying the molecular bases of midbrain dopamine neuron function and survival. Midbrain dopamine neurons are thought to play a key role in learned and addictive behaviors, and degeneration of these neurons underlies Parkinson's disease. One focus of the lab is to understand the mechanisms by which mutations in two genes, a-Synuclein and Parkin, can lead to familial Parkinson's disease, and how these mechanisms relate to the normal cellular roles of these genes. We are employing molecular biological, cellular and mouse genetic techniques to identify the physiological and pathological interactions and functions of the proteins encoded by these genes. Another interest of the lab relates to the regulation of dopamine release at central synapses and whether such regulation is important for dopamine neuron survival.
Ernest W. April, Ph.D., P&S 10-425, Ext. 5-5631
Muscle biophysics. Studies concerning the myofilament lattice, liquid crystals in biological systems, and malignant hyperthermia. Clinical anatomy.
Richard Baer, Ph.D., Russ Berrie 313A, 851-5275
BRCA1 and BARD1 function in breast cancer.
Jonathan M. Barasch, M.D., Ph.D., P&S 10-501, Ext. 5-1890
Epithelial cells of the kidney derive from mesenchymal cells and form the nephron, the functional unit of the organ. The conversion of mesenchyme into epithelia is controlled by the ureteric bud. Our work is dedicated to identifying signals from the ureteric bud that induce cell conversion, the cellular mechanisms that lead to the epithelial phenotype (de-novo), and the identification of the progenitors of the organ.
Jeannette Chloe Bulinski, Ph.D., Fairchild 804, Tel. 854-5570
Differentiation of cytoskeletal elements during morphogenesis. Expression and post-translational modifications of microtubule-associated proteins and tubulin functioning in mitosis and in skeletal and heart muscle differentiation.
Giorgio Cattoretti, M.D., Russ Berrie 303, 851-5279
The pathogenesis of lymphoid neoplasia in humans and animal models.
Lorraine N. Clark, Ph.D. P&S 12-404, ext. 56405
Molecular genetics of Parkinson's Disease.
Vivette D'Agati, M.D., VC 14-224, Ext. 5-6269/5-7460
Histologic, immunopathologic and ultrastructural studies of medical diseases of the kidney. Research projects include murine model of polycystic kidney disease, and clinical pathologic studies of HIV nephropathy, lupus, nephritis, focal segmental glomerulosclerosis and diabetic nephropathy.
Riccardo Dalla-Favera, M.D., Russ Berrie, Rm. 303, Ext. 2-7380
The general goal of this laboratory is to elucidate the pathogenesis of cancer. We focus on lymphoid malignancies and on the identification of genes that control B cell development and are altered in lymphoma. Altered genes, including oncogenes and tumor suppressor genes, are studied for their normal and pathologic functions using in vitro molecular biological assays as well as transgenic mouse models.
Thomas Diacovo, M.D., ICRC, Rm. 202A, Tel., 212-851-4683
Publications from research include, "Mechanics of transient platelet adhesion to von Willebrand factor under flow." and "Adhesive mechanisms governing IPC recruitment into Lymph Nodes."
Gilbert Di Paolo, Ph.D., P&S 12-403, ext. 2-4775
Role of phosphoinositides in organelle trafficking, cytoskeletal dynamics and disease-related processes.
Fiona Doetsch, Ph.D., P&S 14-511, Tel. 342-5633
Neural stem cells and their niche in the adult mammalian brain.
Andrew J. Dwork, M.D., PI 1504, Tel. 960-5563
The major focus of this laboratory is the study of neuroanatomic correlates of psychiatric disorders such as schizophrenia, mood disorders and suicide. In particular, we are interested in the causes of cognitive impairment among individuals suffering from these disorders. Of related interest are the neuroanatomic effects of external influences, such as chronic hospitalization, somatic treatments, and intellectual stimulation.
Phyllis L. Faust, M.D., Ph.D., BB 1428, Ext. 5-7345
Investigation of human neuronal migration disorders. We have utilized gene targeting to develop a mouse model for the peroxisomal biogenesis disorder Zellweger syndrome. We are characterizing the central nervous system abnormalities that develop in these mice with morphologic, molecular and biochemical methods.
Daniel Fink, M.D., MPH, PH3W-363, Ext. 5-6487
Informatics in the clinical laboratory. Director of Core Laboratory, CUMC.
Paul B. Fisher, Ph.D., BB 1501, Ext. 5-3966
Molecular basis of carcinogenesis and cellular differentiation.
Greg A. Freyer, Ph.D., HHSC 523, Tel. 543-4125
Molecular Biology and Biochemistry. Repair of UV damaged DNA and the regulation of this process.
Michael D. Gershon, M.D., P&S 12-513, Ext. 5-3447
Neurobiology, neuroanatomy and developmental neurobiology. A variety of studies concerning the enteric neuronal systems, from the migration of neural crest neuroblasts to the gut, to tissue interactions in development which lead to congenital megacolon.
James E. Goldman, M.D., Ph.D., P&S 15-420, Ext. 5-3554
Cellular and molecular studies of astrocyte and oligodendrocyte development and myelination; glial responses to pathological states, including demyelinating diseases; regulation and function of heat shock proteins in CNS glia; cytoskeletal proteins of neurons and glia; neurodegenerative diseases.
Ellen Greenebaum, M.D., PH 1592, Ext. 5-6719
Cytopathology with special emphasis on Fine Needle Aspiration Biopsy, especially of thyroid, head and neck and ovarian cysts.
Lloyd A. Greene, Ph.D., P&S 15-401, Ext. 5-6369/6370
Cellular and molecular biology of neuronal development. Studies on the molecular mechanisms by which neurotrophic factors regulate neuronal differentiation and death. Investigations of the causes and prevention of neuronal cell death and degeneration.
Wei Gu, Ph.D., Russ Berrie 412C, 851-5282
Molecular mechanisms by which p53 mediates tumor suppression and responses to cellular stress.
Gregg G. Gundersen, Ph.D., BB 1217, Ext. 5-1899
Cell Biology. Cytoskeletal dynamics in cell motility and cell polarization. Role of microtubules in organelle transport.
Diane Hamele-Bena, M.D., VC 14-238, Ext. 5-2360
Cytopathology and Surgical Pathology, with special interest in the pathology of breast diseases. Also involved in using multimedia tools in medical education.
Arthur P. Hays, M.D., P&S 14-442, Ext. 5-3734
Morphologic methods are used to study peripheral nerve in motor neuron diseases, diabetic neuropathy and autoimmune neuropathies.
Christopher E. Henderson, Ph.D., HHSC 6-616, Ext. 2-4086
Work in the lab focuses on the study of motor neuron development as an approach to understanding and analyzing mechanisms underlying ALS and SMA.
Hanina Hibshoosh, M.D., VC 14-209, Ext. 5-6739
Surgical pathology, breast and soft tissue tumors. Molecular pathogenesis of breast tumors as well as evaluation of prognostic factors related to breast cancer utilizing image and molecular analysis.
Harold S. Kaplan, M.D., HP 4-417, Ext. 5-2677
Research on human error in medicine, its prevention and management.
Richard H. Kessin, Ph.D., P&S 12-517, Ext. 5-5653
Molecular Biology and Genetics. Gene regulation and development in simple organisms. Specific proteolysis during development. Evolution of developmental strategies.
Tae Wan Kim, Ph.D., P&S 14-411, Ext. 5-8756
Our current research is aimed at elucidating the molecular mechanisms underlying familial Alzheimer's disease (FAD). A significant portion of AD is caused by the inheritance of certain defective genes. Mutations in the genes encoding the presenilins (PS1 and PS2) cause the majority of early-onset cases of FAD. The central focus of our research is to define the precise molecular steps by which defects in presenilin genes lead to the characteristic pathogenesis and molecular phenotypes associated with FAD. Specifically, we are studying the specific roles of the presenilins in calcium signaling as well as proteolytic processing of amyloid precursor protein at the molecular level. Studies in my laboratory utilize a variety of molecular genetic, biochemical and cell biological techniques, including proteomics.
Jan Kitajewski, Ph.D., P&S 16-419, Ext. 5-3624
Wnt and Notch genes in tumorigenesis and vascular development.
Brett Lauring, M.D., Ph.D., BB 1427, Ext. 5-0395
Investigation of the cellular and molecular basis of neurodegenerative diseases. We employed a novel crosslinking strategy to identify and purify proteins interacting with alpha synuclein, a protein that contributes to synaptic plasticity by regulating neurotransmitter release and contributes, particularly when mutated, to the pathogenesis of Parkinson's disease. Out aims include elucidating the mechanism by which synuclein regulates dopamine release and synaptic vesicle trafficking. Other studies focus on biochemical reconstitution of the intra-membrane proteolysis of the amyloid precursor protein, an event central in the pathogenesis of Alzheimer's disease.
Jay H. Lefkowitch, M.D., PH 15W-1574, Ext. 5-7381
Histopathological and ultrastructural studies of diseases of the liver. Special areas of interest include pathology of hepatitis C virus infection, the liver in AIDS, and biliary tract diseases.
Ronald K.H. Liem, Ph.D., P&S 15-421, Ext. 5-4078
Cellular and molecular neurobiology. Studies concerning the composition, organization and function of the neuronal cytoskeleton.
W. Ian Lipkin, M.D., MSPH/EPI, Room 1801, Ext. 2-9033
The role of infectious agents and immune responses in acute and chronic CNS disease including developmental defects, affective disorders and schizophrenia, and autism. The laboratory also focuses on the identification of new viral agents in human disease.
Thomas Ludwig, Ph.D., Russ Berrie Medical Science Pavilion 607, Tel. (212) 851-5234
Functional analysis of breast cancer susceptibility genes. Our efforts are focused on molecular and genetic studies of the breast cancer susceptibility genes BRCA1 and BRCA2. Germline mutations in the BRCA1 and BRCA2 genes account for 70-80% of hereditary breast and ovarian cancers. Both are thought to be tumor suppressor genes as the wild-type alleles are lost in tumors of heterozygous carriers. BRCA1 and BRCA2 encode novel proteins, but primary amino acid sequences yield little information about their normal function. Extensive research efforts from all disciplines contributed a plethora of data suggesting a role for both, BRCA1 AND BRCA2 in embryonic proliferation, homologous recombination and DNA repair pathways, cell cycle checkpoint control and, transcriptional regulation. However, it is unclear which function(s) specifically suppress tumorigenesis. TP53 is mutated in a large number of BRCA-associated tumors consistent with the hypothesis that inactivation of a cell cycle checkpoint is a necessary step and may precede BRCA loss during tumorigenesis. Using embryonic stem cell technologies we are generating mice with specific mutations in BRCA1 and BRCA2 to understand how loss of their function leads to early onset breast and ovarian cancer, and to generate animal models of the human disease.
Mahesh Mansukhani, M.D., VC14-236, Ext. 5-2646
Molecular pathology including screening and diagnosis.
Yinghui Mao, Ph.D., P&S 14-460, Ext. 5-7914
Kinetochore microtubule attachment, chromosome movement, and mitotic checkpoint during mitosis
Charles C. Marboe, M.D., PH 15W-1576, Ext. 5-8063
Surgical pathology. Cardiac and pulmonary transplant pathology. Special interest in cardiac pathology: atrial fibrillation and remodeling after assist device placement.
Eugene E. Marcantonio, M.D, Ph.D., BB 1427, Ext. 5-2017
Cell Adhesion. Integrin receptor role in interactions with the cytoskeleton and in growth promoting signals. Systems include fibroblast adhesion and migration; transgenic mouse models of the developing thymus and T cell activation and proliferation.
Glen S. Markowitz, M.D., VC 14-224, Ext. 5-7460
Renal pathology utilizing modalities of light microscopy, immunofluorescence and electron microscopy. Research interests include animal models of autosomal dominant polycystic kidney disease, nephrotoxicity of various therapeutic agents (including lithium and pamidronate), and clinico-pathologic studies of multiple glomerular diseases including lupus nephritis, membranous glomerulopathy, focal segmental glomerulosclerosis and fibrillary glomerulonephritis.
Carol A. Mason, Ph.D., P&S 14-509, Ext. 5-2105
Developmental neurobiology. Axonal growth cone interactions with pathways, and with target cells; development of synaptic connections.
Umrao R. Monani, Ph.D., HHSC 617, ext. 5-5244
Spinal muscular atrophy-translating basic findings into a potential treatment.
Letty Moss-Salentijn, D.D.S., Ph.D., P&S 12-451, Ext. 5-5647; 5-8334
Prenatal growth and development of the facial complex. Growth dynamics of the postcranial skeleton with special emphasis on endochondral ossification processes in long bone growth.
Vundavalli Murty, Ph.D., P&S 15-408, Ext. 5-7914
Major focus of this laboratory is to understand the genetic basis of male germ cell tumors and carcinoma of cervix uteri. General interest is to utilize cytogenetic and molecular cytogenetic methods in diagnosis and prognosis of cancer.
David Michael Owens, Ph.D., 1130 St. Nicholas Ave. Rm. 309A, tel. 212-851-4544
Our overall focus is to determine the contributions of stem cells and differentiated cells to the development of epidermal squamous cancer.
Kathleen M. O'Toole, M.D., VC 14-209, Ext. 5-6719
Pathology of the male genital and urinary tracts, with an emphasis on neoplasms. Clinicopathologic studies of these entities, utilizing immunohistochemical techniques.
May Parisien, M.D., PH 15W-1575, Ext. 5-7572
Study of metabolic bone diseases, specifically, the microarchitecture of bone in primary hyperparathyroidism, using the technique of bone histomorphometry.
Ramon Parsons, M.D., Ph.D., Russ Berrie Research Center,
1150 St. Nicholas Avenue, Rm. 302, Tel. 304-7385
Our lab focuses on the PTEN tumor suppressor gene, which is mutated in a variety of cancers. We are attempting to determine its role in regulating tumor growth.
Karl H. Perzin, M.D., VC 14-212, Ext. 5-9857
Clinocopathologic study of breast biopsy specimens to determine if precursor lesions to breast carcinoma can be identified. Clinocopathologic studies of various tumors of the head and neck region, and of the gastrointestinal tract, including immunohistologic studies.
Michael A. Pesce, Ph.D., BHS 4-406, Ext. 5-6569
Clinical Chemistry: Studies that determine the sensitivity and specificity of the biochemical markers creatine kinase MB, isoforms, creatine kinase MB, troponin and myoglobin in the assessment of myocardial infarction and unstable angina.
Tuan D. Pham, Ph.D., P&S 12-402, Ext. 5-3445
Developmental neurobiology. Studies of the relationship between birthdates and phenotypic expression of neurons during embryonic development using immunocytochemical, radioautographic and ultrastructural techniques.
Liza A. Pon, Ph.D., P&S 12-425, Ext. 5-1947
Cell biology. Protein import into mitochondria; control and regulation of mitochondrial movement during yeast cell growth and development; myosin I function in establishment of cell polarity.
Stephen Rayport, M.D., Ph.D., P.I. Room 1503, Tel. 960-5641
Physiology and pharmacology of mesolimbic dopamine neurons examined in vitro.
Ralph Richart, M.D., VC14-229, Ext. 5-3623
The pathogenesis of uterine cervical neoplasia and methodologies to detect and prevent precursor lesions.
Steven Rosenfeld, M.D., Ph.D., N.I. Mail Code 2, Ext. 5-2700
Research focuses on novel ways of pharmacologically blocking brain tumor growth and invasiveness by targeting the molecular motors that drive mitosis and cell motility.
Lorna W. Role, Ph.D., PI Annex 807, Tel. 543-5929
Developmental regulation and modulation of ion channels expressed in central and peripheral neurons.
Heidi Rotterdam, M.D., VC 14-213, Ext. 5-7782
Surgical Pathology. Clinicopathologic studies of gastrointestinal pathology and infectious disease processes, especially the infectious complications of AIDS.
Michael L. Shelanski, M.D., Ph.D., P&S 15-401, Ext. 5-3300
Studies on the chemistry and regulation of the cytoskeleton in cell division and in differentiation of nerve cells and astroglia. Investigations of the role of the cell surface in interactions between neurons and glial cells. Cell biological studies of degenerative neurological diseases and brain tumors.
Ann-Judith Silverman, Ph.D., P&S 12-460, Ext. 5-3540
Neurobiology. Migration of neuronal and immune system cells in the CNS.
Ila Singh, M.D., Ph.D., P&S 14-453, Ext. 5-4263
Our laboratory studies the mechanisms of viral infection using genetic, biochemical and cell biological approaches. We use innovative, high-throughput techniques to study the processes of virus-cell interaction and viral replication. We have developed a novel technique called genetic footprinting, which allows thousands of precisely defined mutations to be made and analyzed en masse in order to define functionally essential features in the sequence of interest. We are applying genetic footprinting to retroviruses, including Moloney murine leukemia virus (Mo-MLV) and human immunodeficiency virus (HIV) and to hepatitis C virus. The goal is to understand the precise roles of every sequence in the entire viral genome, in the different steps of infection. We are also studying HIV coreceptors in order to elucidate the mechanisms of virus-cell interaction and of viral entry. These analyses are geared towards achieving a better understanding of the process of viral infection.
Steven Spitalnik, M.D., P&S 15-408, Ext. 2-5648
Biology of the human glycophorin blood group antigens. Glycobiology of Toxoplasma gondii. Director of Laboratory Medicine with subspecialty expertise in transfusion medicine. Director of Clinical Laboratories at CUMC.
Gloria Huei-Ting Su, Ph.D., P&S 11-451, Ext., 5-1701
Molecular genetics of head and neck squamous cell carcinoma and pancreatic ductal adenocarcinoma, as well as mouse modeling for both cancer types.
Nicole Suciu-Foca, Ph.D., P&S 14-401, Ext. 5-6941
Immunogenetic studies of the immune response to HLA antigens using serology, cellular immunology and molecular biology approaches. Studies of lymphocyte receptors for growth and differentiation factors. Cell biological studies of antigen specific T suppressor cells.
Matthias J. Szabolcs, M.D., P&S 16-440, Ext. 5-4637
My special interest is the study of myocardial damage caused by ischemia and inflammation with particular focus on nitric oxide mediated pathways. This also involves NO-related mechanisms which act during acute and chronic cardiac allograft rejection. Tissues are analyzed by molecular, biochemical and immunohistochemical means.
Ira A. Tabas, M.D., Ph.D., BB 1006, Ext. 5-2120
Cell biology. Pathways and enzymology of intracellular cholesterol metabolism in macrophages.
Hadassah Tamir, Ph.D., PI 1804, Tel. 960-5837
Mechanisms of storage and release of neurotransmitters.
Harshwardhan M. Thaker, M.D., Ph.D., P&S 14-451, Ext. 5-1174
Pediatric and perinatal pathology. Pathogenesis of stillbirth and congenital malformations. Pediatric tumor biology. Tumor and tissue banking.
C. Dominique Toran-Allerand, M.D., BB 1615, Ext. 5-3620
Developmental neurobiology: Influence of sex steroids and growth factors and their interactions in the nervous system development. The distribution, responses and control of three key elements involved in estrogen action in the developing brain: the cellular target, the receptor system (mRNA and protein) and the responsive genes.
Carol Troy, M.D., Ph.D., P&S 15-401, Ext. 5-3119
Molecular mechanisms of neuronal death in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis with an emphasis on the regulation of caspase activity.
Benjamin Tycko, M.D., Ph.D., Russ Berrie, Ext. 2-7165
Molecular biological studies on genomic imprinting in human and mouse systems. Molecular genetics of pediatric tumors. Molecular genetics of Alzheimer's disease.
Richard B. Vallee, Ph.D., P&S 15-409, Tel. (212) 342-0546
Dr. Vallee's lab studies the cell and molecular biology of the microtubule motor protein cytoplasmic dynein in cell division, organelle and viral transport, and directed cell migration; the role of the dynein-related LIS1 gene in brain developmental disease and neuronal stem cell migration; and the structure of the dynein molecule. Dr. Vallee's lab also studies the structure and function of the endocytic GTPase dynamin.
Hynek Wichterle, Ph.D., P&S 14-434, Ext. 5-2704
The use of stem cells to study the development and function of the nervous system.
Joan W. Witkin, Ph.D., P&S 12-435, Ext. 5-1613
Neuronal and glial interactions: light and electron microscopy of development, steroid environment and aging of the hypothalamic-pituitary-gonadal system.
Howard J. Worman, M.D., P&S 10-509, Ext. 5-8156
Molecular cell biology of the nuclear envelope, its biogenesis, dynamics in cell division and pathobiology in cancer. A second project in our laboratory is examining the cell biology of the hepatitis C virus.
Thomas Wright, M.D., P&S 16-404, Ext. 5-3531
Studies on the development of cervical neoplasia and the role of human papilloma virus in human disease.