Konstantina Alexandropoulos, Ph.D., P&S 7-421, Ext. 5-2705
The work is directed towards understanding the regulation and signaling mechanisms of the Src family of non-receptor tyrosine kinases, and how the oncogenic properties of these proteins relate to cancer and apoptosis. These enzymes are critical for normal cellular processes and, when mutated, cause cellular transformation and play a pivotal role in the pathogenesis and progression of human cancers.
J. Thomas Bigger, Jr., M.D., PH 9-103D East, Ext. 5-5058 (Medicine)
Cardiovascular and clinical pharmacology; clinical pharmacology of antiarrhythmic drugs; clinical electrophysiology of the heart; role of the autonomic nervous system in ischemia, arrhythmias, and sudden cardiac death; prediction and prevention of sudden cardiac death.
John P. Bilezikian, M.D., PH 864 West, Ext. 5-6238 (Medicine/Endocrinology)
Regulation of adenylate cyclase, phospholipase C, and other effectors of hormonal action by parathyroid hormone and parathyroid hormone-related protein; clinical and basic features of metabolic bone diseases such as primary hyperparathyroidism and osteoporosis.
Penelope A. Boyden, Ph.D., P&S 7-464, Ext. 5-7907
Cardiac physiology, pharmacology, and pathophysiology: cellular electrophysiology and mechanisms of arrhythmias in artificial and naturally occurring animal models of disease.
Steven J. Feinmark, Ph.D., BB 703, Ext.5-3567
Arachidonic acid metabolism in vascular and inflammatory cells: leukotriene and prostaglandin synthesis, biological and pharmacological activities.
Gerald Fischbach, M.D.
Harold and Margaret Hatch Professor; and Professor of Pharmacology (in the Center for Neurobiology and Behavior) Developmental neurobiology: molecular control of the formation and maintenance of synapses.
Thomas F. Franke, M.D., Ph.D., P&S 7-430, Ext. 5-0420
Cell growth and survival is a major focus in the study of autoimmune and neurological disorders and cancer diseases as well as in the search for novel approaches to their treatment. Thus, the long-term research objective of this laboratory is to elucidate the molecular basis for differentiation, proliferation and survival of mammalian cells.
Daniel J. Goldberg, Ph.D., BB 709, Ext. 5-3578 (Neurobiology and Behavior)
Cellular neurobiology; cellular and molecular events underlying axon growth and the response of neurons to injury.
Joseph H. Graziano, Ph.D., 60 Haven Ave., Ext. 5-1678 (Public Health)
Clinical pharmacology; biochemical and epidemiologic studies of heavy metals in man; chelation therapy for the treatment of lead poisoning; mercury poisoning, and iron-overload.
Steven Greenberg, M.D., P&S 9-501, Ext. 5-1586 (Medicine)
The laboratory has studied functional aspects of macrophages, particularly phagocytosis. We have utilized several model systems to dissect the signal transduction cascades that underlie phagocytosis by Fc?¥ receptors. Fc?¥ receptors belong to a family of signal-transducing receptors which share certain common features, including association with immunoreceptor tyrosine kinase activation motif (ITAM)-bearing subunits, whose tyrosine residues become phosphorylated upon receptor ligation and clustering.
Ren?© Hen, Ph.D., PI Annex 729, Tel. 543-5328
(Psychiatry) (Center for Neurobiology and Behavior)
Research is aimed at understanding how neuromediators like serotonin modulate a variety of physiological states such as appetite and emotions as well as pathological states such as depression and anxiety. Transgenic mice and gene targeting techniques are used to study the contribution of individual serotonin receptors to these behaviors.
Brian F. Hoffman, M.D. (Emeritus), PH 316 West, Ext. 5-8368
Cardiovascular physiology and pharmacology.
Jonathan A. Javitch, M.D., Ph.D., P&S 11-401, Ext. 5-3973 or 5-3974
(Center for Molecular Recognition/Psychiatry)
G-protein coupled receptors: the structural bases for pharmacological specificity and signal transduction; catecholamine transporters: the structural bases for substrate transport and its inhibition by cocaine. We have developed a new, systematic approach to identifying the amino acid residues in membrane-spanning segments that are water-accessible and form the surface of the binding site-crevice of catecholamine receptors. Our approach combines site-directed mutagenesis, functional expression, and covalent chemical modification. We are also pursuing structure/function studies in the dopamine and norepinephrine transporters.
Norman Kahn, D.D.S., Ph.D., (Emeritus) PH 7-316 West, Ext. 5-8369
Associate Dean, School of Dental and Oral Surgery (Emeritus).
Robert S. Kass, Ph.D., PH 7-318 West, Ext. 5-7444 (Center for Neurobiology & Behavior)
The research in our lab focuses on the regulation and expression of ion channel proteins in normal and genetically-altered heart. Transgenic mouse models, as well as expression of recombinant ion channels in mammalian cells are used to study these problems.
Andrew R. Marks, M.D., P&S 9-401, Ext. 5-0270 (Medicine)
A major focus of the laboratory is the characterization of the single channel properties of the cloned expressed ryanodine receptor (RyR)/calcium release channel of the sarcoplasmic reticulum that controls excitation-contraction (EC) coupling in cardiac and skeletal muscle.
Milton Packer, M.D., Milstein 5-435, Ext. 5-9260 (Medicine)
Pathophysiology of congestive heart failure; mechanisms and pharmacology of new drugs and devices for cardiac disorders.
Geoffrey S. Pitt, M.D., Ph.D., PH 7West-318 (Medicine)
Calcium-dependent gating of L-type calcium channels and regulation of gene transcription.
Alice Prince, M.D., BB 4-418, Ext. 5-4193 (Pediatrics)
Interactions of bacteria and respiratory epithelial cells with respect to the pathogenesis of bacterial infection in cystic fibrosis.
Richard B. Robinson, Ph.D., PH 7-311 West, Ext. 5-8371
Developmental cardiac electrophysiology and signal transduction; membrane biophysics of ion channels associated with cardiac pacemaking activity; regulation of cardiac autonomic receptors and second messenger systems.
Michael R. Rosen, M.D., PH 7-321 West, Ext. 5-8754
Cardiovascular pharmacology: electrophysiology of cardioactive drugs, developmental pharmacology and electrophysiology, cardiac arrhythmias.
Helen E. Scharfman, Ph.D., Helen Hayes Hospital, W. Haverstraw, NY (914) 947-3000 x3859
Neurophysiology and pharmacology of hippocampus, thalamus, and cortex using brain slices; structure and function studies of single neurons; mechanisms underlying hyperexcitability.
Steven A. Siegelbaum, Ph.D., PI Annex 616, Tel. 543-5245
(Center for Neurobiology and Behavior)
Membrane biophysics, pharmacology of excitable membranes; molecular studies of ion channel function; synaptic plasticity in the mammalian brain.
Susan Steinberg, M.D., PH 7-313 West, Ext. 5-4297
Receptor pharmacology: Studies of the molecular changes in components of the adrenergic receptor and signal transduction pathways during normal cardiac development and in experimental models of cardiac ischemia hormonal regulation of cardiac contractile function.
Gareth R. Tibbs, Ph.D., Ext. 5-3516 (Anesthesiology)
Molecular basis of Ih channels and their contribution to cellular signaling in the CNS.
Judah Weinberger, M.D., Ph.D., DAP 438, Ext. 5-1581 (Medicine)
Intracellular sterol metabolism; control of sterol esterification. Mechanisms of restenosis after arterial interventions.
Andrew L. Wit, Ph.D., P&S 7-446, Ext. 5-4197
Cardiovascular physiology and pharmacology: electrophysiology and pathophysiology of myocardial infarction; arrhythmia associated with myocardial infarction, and its modification by antiarrhythmic drugs.
An-Suei Yang, Ph.D., P&S 7-422, Ext. 5-4173 (Columbia Genome Center)
Computational methodologies aimed at elucidating structural and functional roles of amino
acids in proteins.