John D. Allendorf, M.D., jda13@columbia.edu Research involves innovative management of hepatic metastases.
Michael Argenziano, M.D., ma66@columbia.edu Several trials of robotic cardiac surgery and surgical treatment of atrial fibrillation. Basic science and clinical laboratory focused atrial fibrillation, minimally invasive cardiac surgery, and cardiovascular physiology.
Marc S. Arkovitz, M.D., ma2161@columbia.edu Genetics of lung development, pulmonary hypertension and congenital diaphragmatic hernia (CDH). We have developed collaborations with cardiology, genetics and neonatology.
Jeffrey Ascherman, M.D., jaa7@columbia.edu Research involves studies of cranial volumes in children, sternal wounds, and different techniques of breast reconstruction following mastectomy.
Marc Bessler, M.D., mb28@columbia.edu Principal investigator of LAP BAND® clinical trial, targeted toward patients who are not heavy enough for weight loss surgery based on standard criteria, but are suffering from medical problems and quality of life issues.
Robert S. Brown Jr., M.D., M.P.H., rd464@columbia.edu Principal investigator of Viser I trial, a study comparing the standard treatment for chronic Hepatitis C to a new therapy.
Jonathan M. Chen, M.D., jmc23@columbia.edu Studies related to surgery for congenital heart disease, transplantation and mechanical ventricular assistance. Alternative anticoagulants for cardiopulmonary bypass and cardiac physiology in animal models of congenital heart disease.
Robert A. Cowles, M.D., rc2114@columbia.edu Clinical and Basic Science aspects of short gut syndrome. Collaboration developed with Michael Gershon (Anatomy) to study the role of the enteric system in regulating adaptation after bowel resection in mice; effects of chemotherapy on intestinal transit; outcomes in biliary atresia, choledochal cyst, congenital intestinal disorders and intestinal rehabilitation.
Rajeev Dayal, M.D., rd282@columbia.edu Outcomes analysis using institutional, state-wide and national datasets to determine whether carotid stenting is equivalent to cartoid endarterectomy for stroke prevention.
Mahmood El-Tamer, M.D., me180@columbia.edu Estrogen metabolism and breast cancer. Defining quality of care in breast cancer. The role of MRI in breast cancer.
Dennis L. Fowler, M.D., dlf91@columbia.edu Investigation of the different tissue ingrowth into different mesh hernia prostheses in animals. Clinical investigation of the impact on the outcome of laparoscopic surgical procedures when performed by residents after training on a virtual simulator.
Annetine Gelijns, Ph.D., acp10@columbia.edu Directs data coordinating centers for clinical trials in surgery.
Mark E. Ginsburg, M.D., meg18@columbia.edu Co-investigator of Endobrochial Valve for Emphysema Palliation Trial (VENT), a minimally invasive alternative to lung volume reduction surgery (LVRS).
Robert T. Grant, M.D., M.S., rg424@columbia.edu 1) Post-approval study of silicone gel breast implants, 2) the on-going study of silicone gel implants in patients who received these devices for reconstructive reasons, 3) musculoskeletal complaints, 3) physical fitness and nutrition habits of surgical trainees and Attending surgeons, and 4) the expanded role for electroceutical devices in post-op wound healing and pain control, 5) Clinical scar outcomes using the Insorb skin stapler system.
James V. Guarrera, M.D., jjs46@columbia.edu Abdominal organ preservation and ischemia reperfusion injury in liver transplantation and hepatobiliary surgery. Translational research involving machine perfusion of abdominal organs and other interventions to ameliorate preservation related injury in transplantation.
Andrew A. Gumbs, M.D., ag2462@columbia.edu Minimal access hepato-pancreato-biliary surgery and the link between obesity and pancreatic carcinogenesis.
Mark Hardy, M.D., mah1@columbia.edu 1) induction of transplantation tolerance both in vitro with human cells and in vivo in various animal models; 2) Clinical islet transplantation and development of new methods of pancreatic islet isolation, placement, and PET imaging in experimental animal models; 3) Conduct of clinical trials with new immunosuppressive agents in renal transplant recipients and use of other agents in wound healing.
WB Inabnet, M.D., FACS, wbi2102@columbia.edu 1) Primary hyperparathyroidism: Non-classical manifestations, 2) Relationship between hyperparathyroidism and cardiovascular disease, 3) effect of gastric restriction and malabsorption on gut petides and diabetes in a rat model.
Silviu Itescu, M.D., si5@columbia.edu Two clinical trials testing the therapeutic potential of adult stem cells in human patients with heart disease.
Dominique Jan, M.D., dj2107@columbia.edu In collaboration with the Department of Pediatric GI and the Institute of Human Nutrition, biological and nutritional studies on intestinal failure, parenteral nutrition and associated liver disease.
Kathie-Ann Joseph, M.D., kpr2@columbia.edu Clinical studies that examine targeted therapies for breast cancer and innovative methods to image and treat breast lesions.
Jessica J. Kandel, M.D., jjk47@columbia.edu Angiogenesis in pediatric solid tumor models (Wilms tumor, neuroblastoma, and hepatoblastoma), centering on the role of vascular endothelial growth factor and the response to its inhibition, in terms of altered expression of proapoptotic and tumor suppressor genes by malignant cells and vascular remodeling/genetic changes in endothelial cells.
Howard L. Kaufman, M.D., hlk2003@columbia.edu Development of tumor vaccines and evaluating the effects of the tumor microenvironment on tumor immunity with an emphasis on the immunotherapy of melanoma.
K. Craig Kent, M.D., kckent@mail.med.cornell.edu Outcomes in vascular disease using decision analysis models and evaluation of large data sets.
Seunghee Kim-Schulze, Ph.D. sk2254@columbia.edu Mechanisms of tumor cell-immune cell interactions, immune suppression exerted by myeloid- and lymphoid-derived regulatory cells in cancer patients and monitoring of immune responses in cancer patients treated with immunotherapy.
James A. Lee, M.D., jal74@columbia.edu Research into a novel medical education paradigm (COACH) using technology to enhance training. Research into various aspects of endocrine disease.
James F. McKinsey, M.D., jfm2111@columbia.edu Outcomes analysis for management of complex aortic disease (thoracic and abdominal aorta). Evaluation using national large data sets and institutional outcomes from conventional and new minimally invasive techniques. Development of new technology for minimally invasive treatment of complex anuerysmal aortic disease. Evaluation and treatment using minimally invasive procedures for patients with critical limb ischemia of the lower extremities or carotid artery disease.
William Middlesworth, M.D., wm61@columbia.edu Research in the area of health services, patient safety and improvement.
Maurizio Miglietta, M.D., mm3161@columbia.edu Death prognostication in trauma, infra-red spectroscopy in hypoperfusion states, concept of mobile operating room, 24/7 care surgical delivery model (in conjunction with University HealthSystems Consortium), falls from NYC bridges.
Nicholas Morrissey, M.D., njm2106@columbia.edu Clinical research analyzing the importance of race and ethnicity on the incidence, treatment, and outcome of peripheral vascular disease, focuses on Hispanic and African American patients and their rates of important vascular diseases. Access to healthcare issues and results of treatment. Developing a model to assess the reasons for failure of synthetic arteriovenous grafts and arterial bypass grafts in order to determine methods for preventing failure of these grafts.
Ralph Mosca, M.D., rm891@columbia.edu 1) SVR trial (Single Ventricle Resconstruction: Sano vs BT shunt in the Repair of Hypoplastic Left Heart Syndrome, 2) ACE inhibition in Single Ventricle Lesions, 3) Multi-site Pacing to Improve Ventricular Function Following Repair of Tetralogy of Fallot, 4) Clinical Application of the “Physiologic Pediatric Pulsatile Pump."
Alan J. Moskowitz, M.D., FACP, ajm4@columbia.edu Clinical trials in cardiovascular and cerebrovascular disease, including ventricular assist devices and therapeutic approaches to arteriovenous malformations of the brain.
Yoshifumi Naka, M.D., Ph.D., yn33@columbia.edu Clinical studies of LVAD effects. Basic studies of vein graft disease. Basic studies of arterial remodeling following injury.
Roman Nowygrod, M.D., rn5@columbia.edu Outcomes research on medical errors tracking and reporting; quality of life after open vs. endovascular aneurysm repair; systemic coagulation changes after prosthetic graft implants; prospective study of renal dysfunction after contrast infusion in patients undergoing peripheral arterial endovascular therapies.
Mehmet C. Oz, M.D., mco2@columbia.edu Clinical studies of effects of cardiopulmonary bypass. Innovative methods of mitral repair.
Lloyd E. Ratner, M.D., lr2182@columbia.edu 1) innovative strategies to increase/improve access to organ transplantation, 2) application of minimally invasive and laparoscopic surgical techniques to transplantation, 3) abrogation of humoral immune responses, 4) study of near miss phenomena in regards to surgical morbidity and mortality, and 5) ethical and physiologic concerns in the management of deceased solid organ donors.
Christine Rohde, M.D., chr2111@columbia.edu Efficacy of pulsed magnetic fields in reducing pain and wound healing complications in breast reduction patients, research in rat models on pulsed magnetic fields, a comparison of various new wound closure modalities, breast cancer patient education regarding breast reconstruction, and the long-term follow-up of silicone breast implant patients.
Eric A. Rose, M.D., ear3@columbia.edu Clinical trial focused on patients with end-stage heart failure who have a left ventricular assist device (LVAD) implanted; adult stem cells will be evaluated for their ability to help repair or regenerate the native hearts of these patients, so that the LVAD might be removed.
Benjamin Samstein, M.D., bs212@columbia.edu Mechanisms of antibody mediated rejection and accommodation. We use genetically modified animals in transplant models of kidney and cardiac transplantation to understand B cell immunology. For more information see http://www.columbiasurgery.org/res/immunology/index.html
Ann Marie Schmidt, M.D., ams11@columbia.edu Research focused on a multiligand receptor called Receptor for AGE or RAGE. Studies to access the impact of RAGE on diabetic complications, proinflammatory pathways, tumor growth and invasion, and degenerative orders of the central nervous system are being performed.
Henry M. Spotnitz, M.D., hms2@columbia.edu 1) Changes in LV compliance, systolic function, and mass during cardiac surgery, currently focusing on relationships between ventricular stiffness and outcome in congenital heart disease, including single ventricle, tetralogy of Fallot, and septal defects, 2) Temporary biventricular pacing and pacing optimization for cardiac support in patients after surgery, which includes BiPACS, BIBET and MVPFontan clinical trials. 3) Myocardial protection in cyanotic animals placed on cardiopulmonary bypass.
Charles J. H. Stolar, M.D., cjs3@columbia.edu Research involves studies of Pectus Excavatum.
Bret Taback, M.D., bt2160@columbia.edu Novel approaches to detect micrometastasis and tumor genetic alterations. Principal investigator of a tissue procurement protocol for breast and melanoma.
Qin Wang, Ph.D. qw2109@columbia.edu Lung inflammation and acute lung injury, with emphasis on the mechanisms that regulate leukocyte recruitment in the lung and endothelial cell responses to cytokines during inflammation and cancer immunotherapy.
Richard L. Whelan, M.D., rlw3@columbia.edu Clinical investigation of Cytokine Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), a drug which aims to reduce tumor recurrences in colorectal cancer patients.
Matthew Williams, M.D., mw365@columbia.edu Research in transcatheter valve therapy and combined surgical and interventional approaches to cardiovascular disease.
June Wu, M.D., jw92@columbia.edu Mechanisms of delayed wound healing and diabetes and other conditions, and the efficacy of physical and chemical devices to improve wound healing. Normal and aberrant vasculogenesis in vascular tumors and malformations.
Shi Du Yan M.D., sdy1@columbia.edu The mitochondrial enzyme ABAD to assess its impact on ischemia, tumor and neurodegenerative disease through mitochondira-mediated signal transduction pathway and protein interaction with ABAD.
Jeffrey Zitsman, M.D., jlz2@columbia.edu Ongoing study of the clinical, psychological and biochemical effects of weight loss in obese adolescents following gastic binding.