Mitchell F. Berman, M.D., mfb1@columbia.edu
Computerization of operating room data; outcomes research.
Anthony R. Brown, M.D., arb6@columbia.edu
Regional Anesthesia: Clinical research.
Charles Cain, M.D., cfc15@columbia.edu
Acute and chronic pain management.
Anthony Clapcich, M.D., ajc60@columbia.edu
Effects of anesthetics on somatosensory evoked potential formation.
Marc L. Dickstein, M.D., mld2@columbia.edu
Cardiovascular physiology; right ventricular function.
Charles Emala, M.D., cwe5@columbia.edu
Signal transduction pathways in smooth muscle cells.
Pamela Flood, M.D., pdf3@columbia.edu
Mechanisms of general anesthesia.
Mark J.S. Heath, M.D., mh22@columbia.edu
Spinal cord physiology.
Eric Heyer, M.D., Ph.D., ejh3@columbia.edu
Cerebral functioning: assessment of neurologic function in cardiac surgical and neurosurgical patients. Intraoperative cerebral monitoring: electroencephalography and ultrasonic Doppler.
Carol Hirshman, M.D., cah63@columbia.edu
Signal transduction pathways in smooth muscle cells.
Amy E. Jonassen, M.D., aem1@columbia.edu
Anesthesia for cardiac surgery in neonates.
Desmond Jordan, M.D., daj3@columbia.edu
Summarization of large amounts of patient-specific clinical data using artificial intelligence and the distribution of this electronic information using multimedia formats.
H. Thomas Lee, M.D., tl128@columbia.edu
Role of adensine protection against renal ischemia.
Neeta Saraiya, M.D., ns193@columbia.edu
Cardiac Troponin I as a sensitive myocardial injury marker in neonates with Hypoplastic Left Heart Syndrome (HLHS).
Jack Shanewise, M.D., jss2128@columbia.edu
Cardiovascular anesthesia, transesophageal echocardiography.
Robert Sladen, M.D., rs543@columbia.edu
Critical care medicine.
Arthur Smerling, M.D., ajs8@columbia.edu
Nitric oxide, pulmonary circulation, pulmonary hypertension, psychological impact of anesthesia on children.
Richard M. Smiley, M.D., Ph.D., rms7@columbia.edu
Adrenergic receptor regulation in pregnancy and perioperative period; spinal and epidural
analgesia during labor.
Lena S.Y. Sun, M.D., lss4@columbia.edu
Cardiovascular function and drug responses in adults and neonates. Effect of intrauterine cocaine exposure on neonatal cardiovascular function.
Gareth R. Tibbs, Ph.D., grt1@columbia.edu
Molecular and biophysical understanding of the activation, permeation and modulation properties of hyperpolarization-activated pacemaker channels of heart and brain.
Robert Whittington, M.D., raw9@columbia.edu
Toxicity of cocaine and its metabolites; cocaine toxicity in parturients.
Jay Yang, MSEE, Ph.D., M.D., jy2029@columbia.edu
Synaptic plasticity and chronic pain; virus-mediated synaptic engineering. Mechanisms of anesthetic action.
Richard Axel, M.D., ra27@columbia.edu
Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated.
Kathryn L. Calame, Ph.D., klc1@columbia.edu
Transcriptional regulatory cascades required for terminal differentiation of B lymphocytes and monocyte/macrophages; transformation of preB cells by the v-Abl tyrosine kinase.
Stephen P. Goff, Ph.D., goff@cancercenter.columbia.edu
Retroviral replication; tyrosine kinase oncogenes.
Max E. Gottesman, M.D., Ph.D., meg8@columbia.edu
Regulation of transcription termination in E. coli and bacteriophage; role of cAMP in cell cycle progression and signal transduction in eukaryotes; vitamin A metabolism in the mouse.
Eric Gouaux, Ph.D., jeg52@columbia.edu
Structure, function and chemistry of membrane proteins; X-ray crystallographic, molecular genetic and biochemical approaches.
Eric C. Greene, Ph.D., ecg2108@columbia.edu
Our lab utilizes total internal reflection fluourescence microscopy (TIRFM) to study the molecular machinery involved in the recombination and repair of damaged DNA. Using TIRFM to directly observe single reactions in real-time we can analyze the molecular mechanisms our cells use to fix damaged DNA with a degree of sensitivity not previously possible.
Iva Greenwald, Ph.D., isg4@columbia.edu
Cell-cell interactions, signal transduction, and cell fate choice; genetic and molecular studies of C. elegans development.
Wayne A. Hendrickson, Ph.D., wah2@columbia.edu
Structural biology of macromolecules; differentiation and computational methods.
David Hirsh, Ph.D., dih1@columbia.edu
Molecular genetics of endocytosis in C. elegans; role of cytokines in the mammalian inflammatory and immune responses.
Oliver Hobert, Ph.D., or38@columbia.edu
Genetic programs that control neural development in C. elegans.
Barry Honig, Ph.D., bh6@columbia.edu
Computational biology, bioinformatics, prediction of protein structure and function.
Thomas M. Jessell, Ph.D., tmj1@columbia.edu
Molecular mechanisms of neuronal differentiation, axon guidance and cell recognition in vertebrate development.
Eric Kandel, M.D., erk5@columbia.edu
Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates.
Arthur Karlin, Ph.D., ak12@columbia.edu
Molecular mechanisms of receptor function.
Richard S. Mann, Ph.D., rsm10@columbia.edu
Control of pattern formation by homeotic genes and their downstream targets in Drosophila.
Arthur G. Palmer, III, Ph.D., (Acting Chair) agp6@columbia.edu
Structure, function and dynamics of proteins; fluctuation in chemical and biological systems and nuclear magnetic resonance; and fluorescence spectroscopies.
Burkhard Rost, Ph.D., rost@columbia.edu
Bioinformatics. Goals: sequence analysis, prediction of protein structure and function. Means: statistics and artificial intelligence.
Lawrence Shapiro, Ph.D., lss8@columbia.edu
Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning.
David R. Bickers, M.D., Carl Truman Nelson Professor & Chairman, drb25@columbia.edu
Studies defining the role of exposure to environmental sunlight on the development of non-melanoma skin cancer (NMSC) in mouse models and human populations as well as identifying mechanism-based cancer chemopreventive agents.
Julide Tok-Celebi, M.D., jt165@columbia.edu
Studies focused on the genetic basis of atypical mole syndrome (AMS) by ascertaining families with this disorder, and identifying a locus for AMS through linkage analysis, and ultimately identifying a candidate gene for AMS.
Angela M. Christiano, Ph.D., amc65@columbia.edu
Studies of inherited skin and hair disorders in humans, through a classical genetic approach including genetic linkage, gene discovery and mutation analysis, and most recently, functional studies relating these findings back to basic questions in epidermal biology. A long-range goal of the research is to develop rationally designed genetic therapies for skin and hair diseases by understanding underlying pathogenetic mechanisms.
Karima Djabali, Ph.D., kd206@columbia.edu
Studies the pathophysiological mechanisms of premature aging using human genetic diseases.
Arianna L. Kim, Ph.D., ak309@columbia.edu
Studies focused on the pathogenesis of solar ultraviolet-induced skin cancers and identifying cell growth regulators that their growth. Also studying the mechanism of senescence pathway in cancer cells and their role in inhibitingtumor growth.
Rebecca Morris, Ph.D., rm2046@columbia.edu
Studies defining the role of epidermal and hair follicle stem cells in skin cancer pathogenesis.
Living hair follicle stem cells can be selected by their expression of various biomarkers.
David M. Owens, Ph.D., do2112@columbia.edu
Studies defining the role of stem cells and differentiated cells in the development of epidermal skin cancer both in terms of tumor cell growth and the role of the underlying stroma in tumor growth and metastases.
Andrei Panteleyev, Ph.D., ap374@columbia.edu
Understanding the mechanisms of hair growth control.
Srikala Raghavan, Ph.D., sr2309@columbia.edu
Studies the role of integrins in skin and oral epithelia.and their importance in basement membrane (BM) assembly using conditional gene ablation as well as cells in culture. Intact BM is essential for normal tissue homeostasis and in epithelial-mesenchymal transitions.
Arthur Bank, M.D., bank@cancercenter.columbia.edu
Regulation of human globin gene expression in hematopoietic cells; gene transfer in animals.
Timothy H. Bestor, Ph.D., dhb12@columbia.edu
DNA methyltransferases; epigenetic effects in gene expression.
Marian Carlson, Ph.D., mbc1@columbia.edu
Regulation of the Snf1/AMPK family of metabolic stress response kinases and transcriptional responses to stress in yeast.
Angela M. Christiano, Ph.D., amc65@columbia.edu
Molecular basis of inherited skin and hair disorders in humans and mice.
Franklin D. Costantini, Ph.D., fdc3@columbia.edu
Molecular genetics of mammalian development.
Riccardo Dalla-Favera, M.D., rd10@columbia.edu
Molecular genetics of cancer; molecular pathogenesis of lymphoma and leukemia; genetic control in lymphoid tissue development.
Argiris Efstratiadis, M.D., Ph.D., ae4@columbia.edu
Growth factors in mammalian development; mouse models of tumorigenic pathway; stem cells in normalcy and malignancy.
L. Erlenmeyer-Kimling, Ph.D., le4@columbia.edu
Psychiatric and behavioral genetics.
Jean Gautier, Ph.D., jg130@columbia.edu
Maintenance of genetic integrity; DNA replication and response to DNA damage.
Laura Johnston, Ph.D., lj180@columbia.edu
Control of the cell cycle and growth during development.
Gerard Karsenty, M.D.,Ph.D., gk2172@columbia.edu
Biological bases controlling skeletal development and physiology.
Virginia E. Papaioannou, Ph.D., vep1@columbia.edu
Genetic control of mammalian development from peri-implantation stages through organogenesis; determination of the role of T-box genes in development, using embryonic stem-cell technology and targeted mutagenesis.
Rodney Rothstein, Ph.D., rothstein@cancercenter.columbia.edu
Yeast genetics and cell biology; cellular responses to DNA damage; recombination; control of genome stability.
Eric A. Schon, Ph.D., eas3@columbia.edu
Molecular genetics of neurological and neuromuscular disorders with focus on mitochondrial genetics and diseases.
Gary Struhl, Ph.D., gs20@columbia.edu
Developmental genetics in Drosophila.
Joseph Terwilliger Ph.D., jdt3@columbia.edu
Population genetic epidemiology and gene mapping.
Andrew Tomlinson, Ph.D., at41@columbia.edu
Cellular interactions in Drosophila development.
Dorothy Warburton, Ph.D., cuh@cancercenter.columbia.edu
Human cytogenetics and molecular cytogenetics; epidemiology of congenital malformations and miscarriages; human gene mapping.
I. Bernard Weinstein, M.D., ibw1@columbia.edu
Molecular biology of cancer; genetic toxicology; signal transduction.
Debra J. Wolgemuth, Ph.D., djw3@columbia.edu
Molecular developmental genetics of mammalian gametogenesis and embryogenesis; regulation of the cell cycle during germ cell mitosis and meiosis: role of cyclin A1 in hematopoiesis and leukemogenesis.
Michael H. Wigler, Ph.D., Cold Spring Harbor Laboratory, (516) 367-8376
Genetic approaches to understanding growth control.
Domenico Accili, M.D. , da230@columbia.edu
Insulin resistance, mechanisms of insulin receptor signaling.
Berrie Research Ctr., 1150 St. Nicholas Ave., Tel. (212) 851-5275
Function of the BRCA1 breast cancer susceptibility gene; retinoid signaling in mammary glands.
William S. Blaner, Ph.D., wsb2@columbia.edu
Retinoids and vitamin A metabolism.
Carol N. Boozer, D.Sc., cnb7@columbia.edu
Human and animal models for study of obesity.
David A. Brenner, M.D., dab2106@columbia.edu
Dr. Brenner’s research is to study the regulation of gene expression in the liver and intestines under normal and pathological states.
Angela M. Christiano, M.D., amc65@columbia.edu
Genetic basis of skin and hair disorders in humans, basic epidermal biology.
Jeanine M. D’Armiento, M.D., Ph.D., jmd12@columbia.edu
Metaloproteases and lung pathophysiology.
Richard J. Deckelbaum, M.D., rjd20@columbia.edu
Lipid-gene-cell interactions; lipid emulsion metabolism; free fatty acids and cell lipid-lipoprotein metabolism.
Bernard F. Erlanger, Ph.D., bfe1@columbia.edu
Biologically significant receptors, the relationship of their structures to their metabolic and regulatory activities.
Dympna Gallagher, Ed. D., dg108@columbia.edu
Energy expenditure and body composition at the organ-tissue level, both cross-sectionally and longitudinally, in growth, aging, and Type II diabetes.
Anne A. Gershon, M.D., aag1@columbia.edu
Virus infectivity; infant immunity relevant to viral infections; varicella-zoster virus (VZV), the highly contagious etiologic agent of chickenpox (varicella) and shingles (zoster).
Michael D. Gershon, M.D., mdg4@columbia.edu
Enteric nervous system.
Henry N. Ginsberg, M.D., hng1@columbia.edu
Regulation of plasma lipoprotein metabolism; regulation of apoprotein B secretion from hepatocytes; dietary regulation of plasma lipids and lipoproteins
Ira J. Goldberg, M.D., ijg3@columbia.edu
Lipoprotein metabolism; lipolytic enzymes; endothelial cell biology; atherosclerosis
Maxwell E. Gottesman, M.D., Ph.D., meg8@columbia.edu
Gene transcription and regulation; cancer; thyroid physiology.
Geoffrey R. Howe, Ph.D., gh68@columbia.edu
Nutrition and cancer; radiation and cancer.
Li-Shin Huang, Ph.D., lh99@columbia.edu
Molecular genetics of lipoprotein metabolism in humans and induced mutant mouse models
Sudha Kashyap, M.D., sk48@columbia.edu
Nutritional support of pre-term infants.
Harry R. Kissileff, Ph.D., hrk2@columbia.edu
Psychology of eating disorders.
Sally A. Lederman, Ph.D., sal1@columbia.edu
Biological determinants of pregnancy outcome; metabolic adjustments for pregnancy and lactation; psychosocial factors that influence birth weight and the course of pregnancy; lactational and gestational nutrient needs and the factors that determine them; energy metabolism and body composition changes during pregnancy and lactation.
Rudolph L. Leibel, M.D., rl232@columbia.edu
Biology of weight regulation and the genetic bases of obesity and diabetes.
Cathy L. Mendelsohn, Ph.D., clm20@columbia.edu
Retinoids and development of urogenital tract.
Frederica Perera, Dr.P.H., fpp1@columbia.edu
Molecular epidemiology; risk assessment; carcinogenesis.
Francis Xavier Pi-Sunyer, M.D., fxp1@columbia.edu
Carbohydrate and lipid metabolism; obesity; diabetes mellitus; food intake regulation.
Ravichandran Ramasamy, Ph.D., rr260@columbia.edu
Carbohydrate metabolism and cardiac function.
Lorna Role, Ph.D., lwr1@columbia.edu
The generation, plasticity, and maintenance of cholinergic and cholinoceptive synapses in the mammalian brain.
David Schachter, M.D., ds12@columbia.edu
Calcium metabolism.
Neil S. Shachter. M.D., nss5@columbia.edu
Molecular mechanisms of hypertriglyceridemia using genetic epidemiologic transgenic mouse technique models.
Lawrence S. Shapiro, Ph.D., lss8@columbia.edu
Dr. Shapiro’s research focuses on possible biochemical causes for adult-onset obesity.
Stephen L. Sturley, Ph.D., sls37@columbia.edu
Yeast as a model extracellular and intracellular sterol transport pathway.
Ira A. Tabas, M.D., Ph.D., iat1@columbia.edu
Regulation of intracellular cholesterol esterification (the ACAT reaction) in macrophage; lipoprotein endocytic pathways in macrophages; biochemical consequences of macrophage cholesteryl ester accumulation.
Alan R. Tall, M.D., art1@columbia.edu
Plasma lipoprotein metabolism; atherosclerosis; protein structure/function and mutagenesis; regulation of gene expression; molecular nutrition.
David A. Talmage, Ph.D., dat1@columbia.edu
The role of signal transduction pathways in regulating cellular responses; retinoid effects through signal transduction pathways.
Timothy Wang, M.D., tcw21@columbia.edu
The role of inflammation, cytokines and growth factors in the development of gastrointestinal cancers.
Sharon L. Wardlaw, M.D., sw22@columbia.edu
Neuroendocrine control of pituitary function. Hypothalamic regulation of energy homeostasis. Neuroendocrine-immune interactions.
Christine L. Williams, M.D., MPH, chrisw@pol.net
Dr. Williams’ research has focused on child nutrition and pediatric preventive cardiology, in particular, issues related to lipids and cardiovascular disease risk, as well as obesity in preschool children.
I. Bernard Weinstein, M.D., ibw1@columbia.edu
Molecular mechanisms of carcinogenesis.
Debra J. Wolgemuth, Ph.D., djw3@columbia.edu
Physiology processes underlying the progression of meiosis and differentiation of mammalian germ cells to highly specialized cells which support embryonic development.
Domenico Accili, M.D., da230@columbia.edu
Insulin resistance in diabetes: Genetics, molecular biology and animal models.
Qais Al-Awqati, M.B., Ch.B., qa1@columbia.edui
Developmental biology of the kidney biogenesis of epithelial polarity; chloride channels and
cystic fibrosis.
Gerald Appel, M.D., gba2@columbia.edu
Treatment of glomerulonephritis and the nephrotic syndrome; lipids and renal disease.
Selim Arcasoy, M.D., F.C.C.P., F.A.C.P., sa2059@columbia.edu
Lung transplantation and rejection; lung reduction surgery for emphysema; idiopathic pulmonary fibrosis and pulmonary alveolar proteinosis; pulmonary embolism and thrombolytic therapy.
Deborah Davis Ascheim, M.D., dda18@columbia.edu
Pharmacologic therapies for heart failure; investigational surgical techniques and mechanical assist devices for patients with end-stage congestive heart failure; altered thyroid hormone metabolism in patients with congestive heart failure.
Arthur Bank, M.D., bank@cancercenter.columbia.edu
Gene transfer and expression in bone marrow cells; regulation of human hemoglobin gene expression; molecular biologic analysis of regulation of human globin biosynthesis.
Jonathan Barasch, M.D., Ph.D., jmb4@columbia.edu
The ureteric bud secretes proteins that induce nearby mesenchyme to convert to epithelia and form nephrons. The aim of my work is to identify these factors and to determine how they change cell fate in the embryonic kidney.
R. Graham Barr, M.D., Dr.P.H., rgb9@columbia.edu
Novel risk factors for asthma and chronic obstructive pulmonary disease (COPD).
Randolph C. Barrows, Jr., M.D., barrows@flux.cpmc.columbia.edu
Computerized patient records; information systems in ambulatory care; clinical data warehouses; automated decision support; controlled medical vocabularies; health data modeling; smoking cessation pharmacotherapies and techniques.
Robert C. Basner, M.D., rcb42@columbia.edu
Cardiopulmonary regulation during sleep; autonomic and vascular correlates of sleep-disordered breathing.
Steven R. Bergmann, M.D., Ph.D., srb40@columbia.edu
Paul D. Berk, M.D., pb2158@columbia.edu
The disposition of long chain free fatty acids (FFA); lipid metabolism, transport physiology, obesity, diabetes, and fatty liver, and who is interested in cellular physiology, transport kinetics, cell and molecular biology and translational research methods.
Rachel Bijou, M.D., rb540@columbia.edu
Clinical research in congestive heart failure.
J. Thomas Bigger, M.D., jtb2@columbia.edu
Studies in the prediction and prevention of sudden cardiac death. Studies of the role of the autonomic nervous system in the genesis of malignant ventricular arrhythmias.
John P. Bilezikian, M.D., jpb2@columbia.edu
Regulation of signal transduction pathways by parathyroid hormone and parathyroid hormone-related protein. Clinical and basic features of metabolic bone diseases such as primary hyperparathyroidism; osteoporosis in women and men.
William Blaner, Ph.D., wsb2@columbia.edu
Regulation of vitamin A and retinoic acid metabolism.
David Brenner, M.D., dab2106@columbia.edu
Intracellular signaling in the liver under normal and pathophysiological states; using animal models of human diseases including transgenic mice combined with cultures of primary and immortalized cells to study in particular the role of NFkB and JNK.
Anne Marie Brilliantes, M.D., ab647@columbia.edu
Genetic basis of Type 1 and Type 2 diabetes mellitus with specific emphasis on the cellular and molecular biology of the pancreatic beta cell.
Robert S. Brown, Jr., M.D., M.P.H., rb464@columbia.edu
Determinants of the cost of orthotopic liver transplantation and the impact of organ allocation strategies on cost and outcome; outcomes including quality of life in chronic liver disease; clinical trials in liver disease and transplantation.
Karen Brudney, M.D., Harkness 6, kfb2@columbia.edu
Clincal research on HIV and tuberculosis in Washington Heights and in the Dominican Republic.
Matthew Burg, Ph. D., mb2358@columbia.edu
The role of stress and emotion in CHD related prognosis, and the mechanisms underlying this role.
Daniel Burkhoff, M.D., Ph.D., db59@columbia.edu
Mechanics of the failing heart; experimental models of heart failure; angiogenesis.
Vincent P. Butler, Jr., M.D., vpb2@columbia.edu
Studies of the effects of digitalis and related compounds on nerve conduction in demyelinating disease both in humans (multiple sclerosis) and in mice (experimental allergic encephalomyelitis).
Stephen M. Canfield, M.D., Ph.D., smc12@columbia.edu
T lymphocyte migration; T cell interaction with the extracellular matrix, specifically laminin; molecular structure/function analysis of the 67kD non-integrin laminin binding protein on activated T cells.
Olveen Carrasquillo, M.D., M.P.H., oc6@columbia.edu
Health service/health policy research; access to care/racial and ethnic disparities; the uninsured; minority/Latino health; managed care; Medicare/Medicaid.
Rita Charon, M.D., Ph.D., rac5@columbia.edu
Studies in literature and medicine; imagination as a clinical instrument; patient-doctor discourse; narrative writing in medicine.
Leonard Chess, M.D., lc19@columbia.edu
Functional and molecular biological studies of cell surface molecules involved in T cell function. Basic and clinical studies of T cell subsets important in the immunopathogenesis of autoimmune, infectious and neoplastic diseases.
James Cimino, M.D., jjc7@columbia.edu
Studies in medical informatics, computerized medical knowledge bases and medical decision-making.
Raphael Clynes, M.D., Ph.D., rc645@columbia.edu
Our laboratory studies the role of Fc receptors in autoimmunity and tumor immunity.
David Cobrinik, M.D., Ph.D.,
Function and regulation of retinoblastoma (Rb) family proteins in cell cycle control, development, and oncogenesis; cellular senescence and differentiation.
David J. Cohen, M.D., djc5@columbia.edu
New immunosuppressive therapies in renal transplantaion; renal disease in recipients of heart, liver and lung transplants.
Paolo Colombo, M.D., pcc2001@columbia.edu
We conduct translational (clinical/basic) studies to determine the expression of pro-inflammatory genes in the vascular endothelium of patients with diabetes and of patients with heart failure. Using a novel approach, endothelial cells are biopsied from peripheral vessels of patients, and then characterized by real time PCR, flow cytometry and immunofluorescent analysis.
James Coromilas, M.D., jc47@columbia.edu
Studies on the mechanisms of ventricular tachycardia. Studies of the effects of antiarrhythmic drugs on re-entrant circuits. Studies on ablation of ventricular tachycardia.
Katherine D. Crew, M.D., M.S., kd59@columbia.edu
Breast cancer prevention and control.
Hayes Dansky, M.D., hmd2101@columbia.edu
Identifying cellular and molecular mechanisms by which diabetes and obesity accelerate atherosclerosis and the response to arterial injury.
Jeanine D’Armiento, M.D., Ph.D., jmd12@columbia.edu
Studies on the role of matrix metalloproteinases in disease by the use of transgenic mouse models.
Jonathan David, M.D., FACP, FACG, jd165@columbia.edu
Colon cancer screening; cost issues in healthcare, using endoscopy as a model.
Karina W. Davidson, Ph.D., kd2124@columbia.edu
Behavioral Medicine randomized controlled trials with cardiology patients.
Mario Deng, M.D., md785@columbia.edu
Outcomes evaluation of medical and surgical therapies in advanced heart failure and the underlying molecular and cellular pathophysiology, with specific emphasis on the interleuken-6 cytokine system.
Betty Diamond, M.D., bd2137@columbia.edu
B cell repertoire selection, immune-mediated neuropsychiatric syndromes, induction and pathogenicity of anti-DNA antibodies.
Emily DiMango, M.D., ead3@columbia.edu
Clinical research includes treatment and management of patients with chronic obstructive airway disease (COPD and asthma); member of the National Emphysema Treatment Trial (NETT); caring for patients with pulmonary complications related to cancer and its treatment.
Marco R. DiTullio, M.D., md42@columbia.edu
Echocardiographic assessment of cardiac embolic sources for ischemic stroke, especially aortic plaques. Applications of echocardiography to epidemiologic studies on cardioembolic stroke.
Jay F. Dobkin, M.D., jfd2@columbia.edu
Pathogenesis of pneumococcal infection in AIDS; epidemiology of tuberculosis associated with AIDS.
Phillip Factor, D.O., phf2103@columbia.edu
Mechanisms of pulmonary edema clearance, role and regulation of lung ?ü2-adrenergic receptors, treatment of acute lung injury, gene therapies for acute and acquired diseases.
Anthony Ferrante Jr., M.D., Ph.D., awf7@columbia.edu
Large increases in fat mass lead to obesity and adversely alter blood pressure, insulin sensitivity, serum lipid profiles and cardiac function. Research focuses on identifying cellular and molecular mechanisms by which changes in fat mass alter medically important traits, including insulin sensitivity and cardiac mass.
Robert L. Fine, M.D., rlf20@columbia.edu
Translational cancer research into the mechanisms of cancer drug resistance in the lab to the clinical implementation of novel therapeutic trials to improve outcome based on lab research.
Michael J. Flamm, M.D., Ph.D., mjf3@columbia.edu
Retroviral gene transfer in the treatment of paroxysmal noctural hemoglobinuria.
Robert Foronjy, M.D., rff5@columbia.edu
Emphysema.
Pamela Freda, M.D., puf1@columbia.edu
Clinical studies of pituitary tumors. Adrenal function in HIV infection.
Harold Frucht, M.D., hf2011@columbia.edu
Gastrointestinal malignancies and pre-malignant conditions, specifically hereditary syndromes and cancer genetics; acid hypersecretory states and GI hormone excess syndromes. Translational research in gastrointestinal cancer biology.
Paul Gaglio, M.D., pg2011@columbia.edu
Treatment of viral Hepatitis pre and post liver transplantation, liver regeneration, living donor liver transplantation, fatty liver disease.
Ali Ghavari, M.D., ag2239@columbia.edu
Molecular genetics of renal diseases, in particular glomerular disorders in humans and rodent models.
Elsa-Grace V. Giardina, M.D., evg1@columbia.edu
Heart disease in women; mechanism of action of estrogen and other drugs to reduce cardiac risk in women.
Victor Grann, M.D., M.P.H., vrg2@columbia.edu
Health outcomes, cost-effectiveness and decision analysis, quality of life, and disparities of cancer care and prevention.
William A. Gray, M.D., wg2131@columbia.edu
Peripheral vascular intervention, percutaneous valve therapy, non-surgical modalities for stroke prevention (carotid stenting and patent foramen ovale (PFO) closure), and research into preventing the reoccurrence of disease following successful angioplasty or stenting.
Henry N. Ginsberg, M.D., hmg1@columbia.edu
Assembly and secretion of lipoproteins from cultured liver cells. Studies of insulin resistance and dyslipidemia in transgenic mouse models. Regulation of lipid and lipoprotein metabolism in humans.
Robin S. Goland, M.D., rsg2@columbia.edu
Clinical diabetes studies.
Ira J. Goldberg, M.D., ijg3@columbia.edu
Regulation of human lipoprotein lipase, transport from fat cells to endothelial cells.
Rochelle Goldsmith, Ph.D., rlg11@columbia.edu
Exercise physiology; mechanisms of exercise limitation in heart failure; exercise training and left ventricular remodeling.
Peter H.R. Green, M.D., pg11@columbia.edu
Celiac disease: clinical presentation, manifestations and complications; genetic analysis, immunologic mechanisms and pathogenesis.
Steven Greenberg, M.D., smg8@columbia.edu
Molecular studies of macrophage cytoskeleton. Signal transduction of Fc receptors. Molecular biology of phagocytosis.
Scott Hammer, M.D., smh48@columbia.edu
Antiretroviral therapy; HIV drug resistance; pathogenesis of HIV infection.
Dawn Hershman, M.D., M.S., dlh23@columbia.edu
Clinical trials in breast and gynecologic malignancies, supportive care and cancer survivorship.
Charles Hesdorffer, M.D., hesdorffer@cancenter.columbia.edu
Marrow and stem cell transplant program and the cellular immunotherapy program of Columbia University.
Kevan Herold, M.D., kh318@columbia.edu
Mechanisms of autoimmune diabetes; new approaches to treatment and induction of tolerance to the autoimmune response.
Shunichi Homma, M.D., sh23@columbia.edu
Cardiac hemodynamics studied with transesophageal echocardiography. Stress echocardiography. Relationship of intracardiac shunts to the occurrence of cerebral ischemic events. Intravascular ultrasound. Cost effectiveness of echocardiograph for different disease processes.
Evelyn M. Horn, M.D., emh3@columbia.edu
Neurohormonal mechanisms of adrenergic dysfunction in congestive heart failure; clinical studies in heart failure. Clinical research in primary pulmonary hypertension.
George Hripcsak, M.D., gh13@columbia.edu
Medical informatics: Medical knowledge-based systems; sharing electronic knowledge across institutions; electronic medical record.
Li-Shin Huang, Ph.D., lh99@columbia.edu
Molecular genetics of lipoproteins. Molecular and cellular mechanisms of apo B expression, including transgenic and knockout mouse models for lipid transport and male infertility.
Hong Jiang, M.D., Ph.D., hj4@columbia.edu
Cellular and molecular mechanisms of immunoregulation by the CD8+ T cells in peripheral tolerance; molecular biologic analysis of interaction between CD8+ and CD4+ T cells; CD8+ T cell mediated control of autoimmunity.
Andrew Joe, M.D., akj3@columbia.edu
Evaluating cancer prevention agents and identifying surrogate tumor markers for use in targeted clinical chemoprevention; ongoing translational, patient-oriented projects, in which I am investigating Barrett’s Esophagus and African-American Breast Cancer.
Ulrich P. Jorde, M.D., upj1@columbia.edu
Renin-angiotensin system in congestive heart failure.
Steven Kawut, M.D. , sk2097@columbia.edu
Determinants and prediction of outcome for patients with pulmonaryarterial hypertension and for patients who are undergoing lung transplantation.
Judith Korner, M.D., Ph.D., jk181@columbia.edu
Clinical studies and basic research in the pathogenesis and treatment of obesity and insulin resistance.
Etah Kurland, M.D., esk11@columbia.edu
New therapeutic approaches to the treatment of osteoporosis in men; family studies/genetic studies of osteoporosis.
Donald Landry, M.D., Ph.D., dwl1@columbia.edu
Artificial enzymes directed against cocaine, nerve gas, and other targets; vasopressin deficiency and hypersensitivity in shock.
Rafael Lantigua, M.D., ral4@columbia.edu
Mentoring minority investigators in aging research; genetics of Alzheimer’s Disease.
Seth Lederman, M.D., Ph.D, sl11@columbia.edu
Studies of molecules involved in the interaction of T cells with B cells important in antibody formation. Molecular investigations of cell surface molecules and lymphokines important in immunodeficiency states and autoimmune diseases.
Marianne Legato, M.D., mjl2@columbia.edu
Delineating the differences in men and women’s normal physiology and in their experience of the same diseases.
Rudolph L. Leibel, M.D., rl232@columbia.edu
Molecular genetics and energetics of obesity and Type 2 diabetes in rodents and humans.
Barron H. Lerner, M.D., bhl5@columbia.edu
Medical ethics and the history of medicine, especially regarding breast cancer and informed consent.
Charles J. Lightdale, M.D., cjl18@columbia.edu
Diagnosis and treatment of Barrett’s esophagus and early esophageal cancer; studies in magnification endoscopy, endoscopic ultrasonography and photodynamic therapy.
Franklin Lowy, M.D., fl189@columbia.edu
Research involves the pathogenesis and transmission of Staphylococcus aureus.
Jeremy Luban, M.D., jl45@columbia.edu
Molecular biology of HIV-1 replication and pathogenesis; regulation of T cell cytokine
production.
Jose Luchsinger, M.D., jal94@columbia.edu
Relationship between cardiovascular risk factors and cognition. Relationship between diet and cognition.
Meggan Mackay, M.D., M.S., mcm2123@columbia.edu
Clinical research in autoimmune disease focussing on Systemic Lupus Erythematosus.
Arthur Magun, M.D., amm3@columbia.edu
Clinical trials in the treatment of chronic hepatitis.
Donna Mancini, M.D., dmm31@columbia.edu
Cardiac transplantation; immunosuppressive surveillance and therapy. Mechanisms of exercise intolerance in heart failure.
Andrew R. Marks, M.D., arm42@columbia.edu
Molecular cardiology; structure and function of calcium channels and their regulation in the pathogenesis of heart failure and cardiac arrhythmias.
Steven Marx, M.D., sm460@columbia.edu
Ion channels in the heart and their regulation by kinases and phosphatases through the formation of macromolecular complexes.
Mathew Maurer, M.D., msm10@columbia.edu
Syncope; isolated systolic hypertension; diastolic heart failure.
Roger A. Maxfield, M.D., ram7@columbia.edu
Multicenter clinical trials of bronchoscopic lung volume reduction.
Rachel Miller, M.D., rlm14@columbia.edu
Clinical and basic science research in asthma and allergies, including IL-4 signaling, development of in- utero sensitization to indoor allergens, evaluation of polymorphisms in IL-4Ra.
Jane H. Morse, M.D., jhm4@columbia.edu
Genetics of pulmonary arterial hypertension; pathophysiological role of mutations of BMPR2 and other members of the TGF-B superfamily.
Lori Mosca, M.D., M.P.H., Ph.D., ljm10@columbia.edu
Clinical trials and outcomes research in cardiovascular disease prevention and women’s health; novel technologies to screen for heart disease; effect of preventive therapies on endothelial function.
Alan J. Moskowitz, M.D., ajm4@columbia.edu
Clinical evaluative research of new interventions for cardiovascular disease, (e.g., mechanical ventricular assist devices and endovascular repair of aortic aneurysms). Particular interest in measuring survival, quality of life, and economic impact.
Issam Moussa, M.D., im2132@columbia.edu
Study of cerebral hemodynamics in patients with carotid occlusive disease before undergoing coronary bypass surgery and before and after carotid artery stenting; study of the relationship between peripheral arterial disease and depression; study of outcome of patients undergoing drug-eluting stent implantation in complex coronary anatomy.
Jean Mulder, M.D., jm669@columbia.edu
Clinical investigation of osteoporosis, particularly in young women with premature ovarian failure and in survivors of childhood cancer.
Alfred I. Neugut, M.D., Ph.D., ain1@columbia.edu
Studies in cancer epidemiology and cancer screening.
Gbenga Ogedegbe, M.D., M.P.H., M.S., goo1@columbia.edu
Minority Health Research. Improving medication adherence in hypertensive African-Americans.
Juan Oliver, M.D., jao7@columbia.edu
Angiogenesis during kidney development; ATP-sensitive K+ channels and regulation of vascular tone.
Ariel Pablos-Mendez, M.D., M.P.H., ap39@columbia.edu
Epidemiology of tuberculosis. Epidemiology of cardiovascular disease (elderly and minorities). Clinical preventive services.
Walter Palmas-Molinger, M.D., wp56@columbia.edu
Telemedicine. Prevention of cardiovascular diseases. Effects of nutritional supplementation on chronic, low level serum inflammation. Identification and causes of subclinical atherosclerosis.
Kyriakos Papadopoulos, M.D., kdp29@columbia.edu
Clinical studies of peptide and cell-based immunotherapy for cancer.
Ramon E. Parsons, M.D., Ph.D., rep15@columbia.edu
Genetic and biochemical analysis of breast cancer.
Alessandra Pernis, M.D., abp1@columbia.edu
Molecular mechanisms of B cell development and function.
Daniel P. Petrylak, M.D., dpp5@columbia.edu
Clinical and laboratory research in the mechanism of hormonal and chemotherapeutic resistance in prostate and bladder cancer.
Thomas Pickering, M.D., D.Phil. tp2114@columbia.edu
Behavioral aspects of hypertension and heart disease.
Geoffrey S. Pitt, M.D., Ph.D., gp2004@columbia.edu
Ion channels in the heart and brain; structural and biophysical properties of voltage-gated calcium channels; calcium-regulated gene expression in the heart and brain.
Charles Powell, M.D., cap6@columbia.edu
Lung cancer: CT screening, biomarker development and validation for early diagnosis, molecular epidemiology, gene expression profiles and preoperative risk assessment.
Leroy E. Rabbani, M.D., ler8@columbia.edu
Regulation of vascular smooth muscle cell fibrinolysis and migration; role of thrombosis in atherosclerosis and angioplasty restenosis.
Jai Radhakrishnan, M.D., M.R.C.P., jr55@columbia.edu
Glomerular disease; outcomes research in dialysis and transplantation.
Harry Raftopoulos, M.D., hr43@columbia.edu
Clinical and translational research in the treatment of lung cancer.
Ravi Ramasamy, Ph.D., rr260@columbia.edu
Metabolic basis of ischemic injury and heart failure; molecular and cellular impact of polyol pathway.
James A. Reiffel, M.D., jar2@columbia.edu
Diagnosis and treatment of cardiac rhythm disorders (arrhythmias).
Carlos Jose Rodriguez, M.D., MPH, FACC, cjr10@columbia.edu
Echocardiography and cardiovascular disease epidemiology; particularly hypertensive heart disease among underrepresented minorities.
Michael Rosenbaum, M.D., mr475@columbia.edu
Regulation of body weight and the pathogenesis of type 2 diabetes in adults and children.
David J. Rothman, Ph.D., djr5@columbia.edu
The ethics of human experimentation, in the U.S. and developing countries; the social implications of genetic enhancement technologies; the social and ethical issues in organ donation and transplantation.
Paul Rothman, M.D., pbr3@columbia.edu
Regulation of signaling pathways in normal and malignant lymphocytes. Molecular studies of the immunopathogenesis of allergic disorders.
Moshe Rubin, M.D., mr43@columbia.edu
Wireless Capsule Endoscopy of the small intestine.
Chris Schindler, M.D., Ph.D., cw54@columbia.edu
Cytokine signal transduction and the role it plays in immunity, atherosclerosis and asthma.
Neil Schluger, M.D., ns311@columbia.edu
Our laboratory studies aspects of the human host immune response against tuberculosis.
Larry Schulman, M.D., lls2@columbia.edu
Lung transplantation; clinical studies in immune suppression and lung injury.
Allan Schwartz, M.D., as20@columbia.edu
Hemodynamics of lateral ventricular mechanical devices.
Neil Shachter, M.D., nss5@columbia.edu
Mouse models of triglyceride metabolism.
Elizabeth Shane, M.D., es54@columbia.edu
Metabolic bone disease associated with cardiac, lung, renal, liver and bone marrow transplantation. Pathophysiology and clinical studies of osteoporosis, primary hyperparathyroidism and other metabolic bone diseases.
Steven Shea, M.D., ss35@columbia.edu
Studies in cardiovascular epidemiology and cardiovascular disease prevention.
Shonni J. Silverberg, M.D., sjs5@columbia.edu
Pathophysiology and clinical studies of osteoporosis, primary hyperparathyroidism and other metabolic bone diseases.
Ethel S. Siris, M.D., es27@columbia.edu
Paget’s disease of bone, osteoporosis and metabolic bone diseases.
Robert J. Sommer, M.D., rs2463@columbia.edu
Interventional Catheterization for Adult Congenital Heart Disease; Patent Foramen Ovale: Stroke/Migraine.
Susan F. Steinberg, M.D., sfs1@columbia.edu
Cardiomyocyte beta-adrenergic receptors; basic cellular mechanisms and novel strategies to treat heart failure; protease-activated receptor signal transduction in cardiomyocytes, a link between inflammation and cardiomyopathy.
Leonard Stern, M.D., ls38@columbia.edu
Long-term survival in peritoneal dialysis: contributing factors such as hematocrit; cardiovascular disease prevention in hemodialysis patients using lipid-lowering therapy.
Peter D. Stevens, M.D., pds5@columbia.edu
New technique and outcomes research in pancreaticobiliary diseases and GI bleeding.
Milan N. Stojanovic, Ph.D., mns18@columbia.edu
Oligonucleotide-based fluorescent probes for small molecules and proteins; directed movement of catalytic nanoassemblies; recognition-triggered drug delivery systems; decision-making molecular networks.
Ira Tabas, M.D., Ph.D., iat1@columbia.edu
Mechanisms and consequences of atherosclerotic foam cell formation.
Alan Tall, M.D., art1@columbia.edu
Plasma lipoproteins; cell and molecular biology of atherosclerosis.
Robert N. Taub, M.D., Ph.D., rnt1@columbia.edu
Drug discovery; molecular biology of mesothelioma and sarcoma; clinical trials in sarcoma, mesothelioma and melanoma.
Jie Wang, M.D., Ph.D., jw147@columbia.edu
Experimental models of heart failure; role of coronary circulation in disease regression.
Sharon Wardlaw, M.D., sw22@columbia.edu
Neuroendocrine control of pituitary function; hypothalamic neuropeptides and regulation of energy homeostasis.
Michelle Warren, M.D., mpw1@columbia.edu
Effects of exercise and weight loss on the hypothalamic-pituitarygonadal axis and the metabolic signals to the GnRH pulse generator, and on the development of osteopenia in women. Treatment of the menopausal woman. Effects of puberty on behavior.
Hal Wasserman, M.D., hsw1@columbia.edu
Adjunctive treatments for myocardial infarction; reperfusion therapy; transplant-related coronary artery disease.
I. Bernard Weinstein, M.D., ibw1@columbia.edu
Molecular mechanisms of carcinogenesis, utilizing cell culture systems and molecular genetics; growth factors and signal transduction.
Carrie Welch, Ph.D., cbw13@columbia.edu
Using a mouse genetics approach to identify new genes underlying susceptibility to atherosclerosis and thrombosis.
Robert Winchester, M.D., rjw8@columbia.edu
How HLA genes act as antigen-presenting structures and selectors of the T-cell repertoire to determine susceptibility to auto-immune diseases and influence the outcome of infections such as HIV.
Howard Worman, M.D., hjw14@columbia.edu
Molecular cell biology of the nuclear envelope, its biogenesis, dynamics in cell division and pathobiology in cancer. Cell biology of hepatitis C virus infection.
Yi-Hao Yu, M.D., Ph.D., yy102@columbia.edu
Lipid and energy metabolism, insulin resistance, and diabetes.
K.L. Calame, Ph.D., klc1@columbia.edu
Regulated gene expression during B and T lymphocyte development.
M. Carlson, Ph.D., mbc1@columbia.edu
Snf1/AMP-activated protein kinase family and metabolic stress responses.
F. Chang, M.D., Ph.D., fc99@columbia.edu
Cell division, cell polarity and the cytoskeleton in fission yeast.
R. Clynes, M.D., Ph.D., rc645@columbia.edu
Fc receptor biology in antigen presentation, cellular cytotoxicity and inflammation.
J.E. Dworkin, Ph.D., HHSC 1218, jonathan.dworkin@columbia.edu
Genetics and cell biology of cytokinesis and chromosome segregation in Bacillus subtilis.
B.F. Erlanger, Ph.D., bfe1@columbia.edu
Immunochemistry of nucleic acids and fullerenes and action of intracellular antibodies.
D. Fidock, Ph.D., HHSC 1502, df2260@columbia.edu
Pathogenesis and drug resistance of the Malaria parasite Plasmodium falciparum; genetic manipulation of P. falciparum.
D.H. Figurski, Ph.D., figurski@cancercenter.columbia.edu
Mechanisms of stable maintenance by promiscuous bacterial plasmids; tight adherence by periopathogen Actinobacillus actinomycetemocomitans.
S.P. Goff, Ph.D., goff@cancercenter.columbia.edu
Molecular biology of retrovirus replication; host factors; yeast two-hybrid screens; virus resistance genes; mouse knock-outs.
M.E. Gottesman, M.D., Ph.D., meg8@columbia.edu
Transcription termination in bacteriophage. Roles of cAMP in Xenopus cell cycle progression and steroid biosynthesis. Genetic analysis of retinol metabolism in the mouse.
H. Gu, Ph.D., hg2065@columbia.edu
Molecular regulation of immune system development, function, and diseases.
A.P. Mitchell, Ph.D., apm4@columbia.edu
Molecular genetics of Candida virulence and of Saccharomyces environmental responses.
B.G. Pernis, M.D., mariagps@aol.com
Immunoregulation by T cells.
V.R. Racaniello, Ph.D., vrr1@columbia.edu
Replication and pathogenesis of RNA viruses.
B.V. Reizis, Ph.D., bvr2101@columbia.edu
Regulation of immune system development and stem cell function.
C.W. Schindler, M.D., Ph.D., cws4@columbia.edu
Molecular mechanisms of signal transduction by cytokines and their role in atherosclerosis and asthma.
H.A. Shuman, Ph.D., has7@columbia.edu
Genetics and genomics of L. pneumophilia pathogenesis.
S.J. Silverstein, Ph.D., sjs6@columbia.edu
Gene expression during varicella zoster virus latency and reactivation.
L.S. Symington, Ph.D., lss5@columbia.edu
Genetics and biochemistry of DNA recombination and repair in yeast.
Y. Zou, Ph.D., yz2001@columbia.edu
Molecular mechanisms controlling lymphoid organotgenesis.
Dr. Stanley Fahn, Director , fahn@movdis.cis.columbia.edu
Clinical research involving most aspects of movement disorders: dystonia and tardive syndromes; clinical pharmacology; genetics of movement disorders; clinical and surgical trials of new therapies for Parkinson disease, dystonia and myoclonus; rating scales; and experimental therapeutics for movement disorders.
Dr. Blair Ford, ford@movdis.cis.columbia.edu
Clinical research on Parkinson disease, dystonia, tremor, Tourette syndrome and other movement disorders, including trials of new pharmacological agents, and surgical approaches to Parkinson disease and tremor.
Dr. Steven Frucht, sf216@columbia.edu
Clinical research in the phenomenology and experimental therapeutics of movement disorders, including Parkinson disease, myoclonus, dystonia, chorea and tics. Current projects include clinical trials of new treatments for Parkinson disease, evaluation and development of new treatments for myoclonus, and evaluation and treatment of focal task-specific dystonias, including musician’s dystonia.
Dr. Paul Greene, pg12@columbia.edu
Clinical phenomenology of movement disorders, experimental therapeutics for Parkinson disease, (including transplantation techniques) and botulinum toxin therapy for dystonia.
Dr. Elan D. Louis, edl2@columbia.edu
Clinical, epidemiological, and genetic aspects of essential tremor, Parkinson disease and Huntington disease.
Dr. Cheryl Waters, cw345@columbia.edu
Clinical drug trials for Parkinson disease. Clinical research on other parkinsonian syndromes and movement disorders.
Dr. Asa Abeliovich, aa900@columbia.edu
The study of the molecular basis of midbrain dopamine neuron function and survival. Midbrain dopamine neurons are thought to play key roles in learned and addictive behaviors and degeneration of these neurons underlies Parkinson disease.
Dr. Robert E. Burke, rb43@columbia.edu
Studies of mechanisms of programmed cell death in models of neurodegeneration related to disorders of the basal ganglia, especially parkinsonism. Studies are conducted both in vivo and in vitro, utilizing immunohistochemistry, quantitative morphologic analysis, in situ hybridization, differential display, receptor autoradiography, and enzyme assays.
Dr. William Dauer, kd2165@columbia.edu
Research focuses on creating and characterizing genetic mouse models of basal ganglia disease, generated through the use of gene targeting. The present emphasis is on the characterizing DYT1 and alpha-synuclein mutants, using anatomic, biochemical and behavioral approaches. Additionally, the laboratory is also involved in strategies that allow region and temporal-specific expression of pathogenic protein in the nervous system.
Dr. Serge Przedborski, sp30@columbia.edu
Study of toxin-induced damage to neurotransmitter systems pertinent to movement disorders such as Parkinson disease and Huntington disease. Modes of cell death and free radical-induced toxicity are also investigated. SOD1 mutant transgenic mice serve as a model for amyotrophic lateral sclerosis. Methods include transgenic mice, immunohistochemistry, in situ hybridization, quantitative morphology, receptor binding, HPLC, classical histology.
Dr. David Sulzer, ds43@columbia.edu
Study of dopamine synaptic plasticity and its pharmacological manipulation by drugs used for treatment of Parkinson disease and schizophrenia, as well as modulation by intrinsic synaptic proteins. Investigations also include mechanisms of addictive-drugs associated with dopamine systems and cell culture models of catecholamine neurotoxicity and neurodegeneration. Methods include electrophysiology, electrochemistry, HPLC, quantitative microscopy, molecular biology and neuronal cell culture.
Drs. John Krakauer, jwk18@columbis.edu
Pietro Mazzoni, pm125@columbia.edu
The neurological mechanisms underlying the initiation and control of reaching movement are studied by kinematic, electromyographic analyses, PET, and fMRI in normal humans and patients with cerebral or cerebellar lesions. Deficits in kinematic control are analyzed following a variety of focal lesions, typically stroke. Recovery and restoration of function are emphasized.
Dr. Seth Pullman, sp31@columbia.edu
Clinical neurophysiologic techniques are used to quantify motor disability and study motor control in patients with neurologic disease. These techniques include kinesiologic and EMG methods; reaction and movement time analyses; transcranial magnetic stimulation of the cortex in conjunction with peripheral stimuli; evoked craniofacial and limb evoked motor recovery curves after multiple stimuli; and backaveraging techniques linking EEG to EMG activity. The effects of treatment such as use of intramuscular botulinum toxin injection are also evaluated using physiologic methods. Artificial neural network and engineering techniques are being developed to analyze and quantify movement disorders.
Dr. Mitchell S. Elkind, mse13@columbia.edu
Stroke risk factors and prevention. Focus on different inflammatory markers and infections, such as C. pneumoniae and periodontal disease, as potential causes of atherosclerosis and ischemic stroke. Use of high-resolution duplex doppler ultrasonography as a measure of stroke risk. Clinical trials of neuroprotectants and surgical hemicraniectomy for acute stroke, and antiplatelet and other therapies for stroke prevention.
Dr. Randolph S. Marshall, rsm2@columbia.edu
Behavioral and physiologic investigation of early hemispheric ischemia in patients undergoing therapeutic carotid balloon test occlusions. Evaluation of visual-spatial dysfunction using behavioral and functional imaging methodologies.
Dr. Jay P. Mohr, jpm10@columbia.edu
Research is focused on clinical, radiologic and pathologic correlations of clinical stroke syndromes; doppler studies and cerebral hemodynamics of large-artery disease; arteriovenous malformations (AVMs); studies of the course and outcome of stroke and its various subtypes; cardiac and hematologic risk factors of stroke; and modification of stroke outcome by specific therapies tested in multi-center trials.
Dr. Ralph L. Sacco, rls1@columbia.edu
Research focuses on stroke prevention and risk factor detection, design and conduct of clinical tnials, and neurological outcomes following stroke. The Northern Manhattan Stroke Study (NOMASS) is an NIH funded cohort study of stroke in the community. Dr. Sacco is also co director of the Neuroepidemiology Training Program.
Dr. Clinton Wright, cbw7@columbia.edu
Study of the effect of different forms of vascular disease on cognitive impairment and decline in a population-based study.
Drs. Ronald M. Lazar, ral22@columbia.edu
Randolph S. Marshall, rsm2@columbia.edu
A clinical research unit dedicated to investigation of the behavioral outcomes of strokes and related vascular diseases. Computerized assessment of stroke patients’ behaviors, functional magnetic resonance imaging, superselective arterial amobarbital (Wada) testing, and transcranial Doppler ultrasonography allow measurement of cerebral plasticity with principal focus on the brain’s abilities to compensate for injury.
Dr. E. Sander Connolly, ecs5@columbia.edu
Dr. Augusto Parra, ap2138@columbia.edu
Mechanisms of ischemic injury. Cellular and molecular neuroprotective mechanisms and new therapeutic strategies.
Dr. Eduardo Bonilla, eb19@columbia.edu
Research involving the ultrastructure of membrane systems in normal and diseased human muscle. Procedures utilized involve transmission electron microscopy, immunocytochemistry, and in situ hybridization.
Dr. Mercy Davidson, mmd2@columbia.edu
Morphological, biochemical, molecular genetic and electrophysiological analyses of mitrochondrial encephalomyopathies using transmitochondrial cybrids, skeletal myoblasts, cardiomyocytes and neuronal cells. Studies of tissue-specific effects of mutations associated with these diseases on normal development and function; and cell culture models for devising potential therapeutic strategies.
Dr. Salvatore DiMauro, sd12@columbia.edu
Biochemical and DNA investigations of human metabolic myopathies, including disorders of glycogen metabolism, lipid metabolism, and mitochondrial function.
Dr. Michio Hirano, mh29@columbia.edu
Molecular biology of neuromuscular disorders. Positional cloning techniques are applied to autosomal disorders affecting the mitochondrial genome. Investigations of mutations of mitochondrial DNA in human cardiomyopathies.
Dr. Eric A. Schon, eas3@columbia.edu
Molecular genetic studies of neuromuscular disorders. Current work includes analysis of respiratory chain genes (cytochrome c oxidase) mutations of mitochondrial DNA in human disease, and in vitro gene therapy.
Dr. Arthur P. Hays, aph1@columbia.edu
Morphologic studies of diabetes and other neuropathies and motor neuron diseases.
Dr. Hiroshi Mitsumoto, Director, hm265@columbia.edu
The Center provides a multidisciplinary team approach for patients with ALS and their families. Comprehensive services include access to medical and psychosocial management, innovative therapeutic clinical trials, basic and clinical research, and expertise in palliative and biomedical care.
Dr. Paul Gordon, phg8@columbia.edu
Neuromuscular clinical research, ALS clinical trials and electromyography.
Dr. Petra Kaufmann, pk88@columbia.edu
Muscular dystrophies, mitochondrial myopathies, other genetic diseases of muscle.
Dr. Clifton L. Gooch, clg33@columbia.edu
Understanding diseases of nerve and muscle through electrophysiologic analysis of peripheral nervous system function in patients. Active areas of research include motor unit number estimation in amyotrophic lateral sclerosis (ALS) and related diseases; electrophysiologic assessment of experimental drug effects; single fiber electromyography and its applications in humans and animal models; quantitative electromyography in myopathic and neuropathic disease; development and application of novel electrophysiologic computerized techniques in EMG; and innovative electrophysiologic techniques for clinical and research applications. The laboratory also provides clinical diagnostic services for a wide and varied population of both inpatients and outpatients at the New York-Presbyterian Hospital and the Neurological Institute.
Dr. Louis H. Weimer, lhw1@columbia.edu
Clinical evaluation of central and peripheral causes of dysautonomia and autonomic failure, including autonomic neuropathy, multiple system atrophy, and orthostatic intolerance. Techniques include cardiovascular reflex testing, heart rate variability, tilt-table testing, power spectral analysis, and sudomotor estimation. Quantification of small somatic pain and temperature nerve fiber function in peripheral neuropathy and selective small fiber neuropathy.
Dr. Ronald G. Emerson, rge2@columbia.edu
Generator sources of evoked potentials; sensory processing by the central nervous system; evoked potentials in neurological disorders; technological and systems development. Dipole models of epileptiform discharges; patterns of seizure propagation.
Dr. Frank Gilliam, Director, Comprehensive Epilepsy Center, fg2124@columbia.edu
Clinical and translational research of most therapeutic techniques in epilepsy, as well as comorbid conditions effects on health outcomes in epilepsy; the neurobiology of depression in epilepsy.
Dr. Carl W. Bazil, cwb11@columbia.edu
Investigational trials of novel anticonvulsant drugs; relationship between neurological diseases (especially epilepsy) and sleep; effects of anticonvulsant drugs on sleep and sleep disorders; outcome of epilepsy surgery.
Dr. Hyumni Choi, hc323@columbia.edu
Dr. Lawrence J. Hirsch, ljh3@columbia.edu
Outcomes of epilepsy surgery. Continuous EEG monitoring in NICU patients. Clinical phenomenology and clinical-electrographic correlation studies of non-convulsive status epilepticus. Clinical pharmacology of antiepileptic drugs.
Dr. Steven C. Karceski, sck33@columbia.edu
New approaches to the surgical treatment of extratemporal localization-related epilepsies. Treatment options and decision making. Comparative value of different antiepileptic drug regimens.
Dr. Alison Pack, ap390@columbia.edu
The treatment of women with epilepsy. The treatment of adolescents with epilepsy. Bone and reproductive health in persons with epilepsy.
Dr. Stanley Resor, srr1@columbia.edu
Dr. Tina Shih,
Socioeconomic disparities, patient outcomes research in epilepsy.
Dr. W. Allen Hauser, wah1@columbia.edu
Neuroepidemiology of seizures and epilepsy syndromes with specific interests in identifying and quantitating risk factors for seizure occurrence, prognosis, and the consequences of head trauma. Epidemiology of status epilepticus.
Dr. Dale Hesdorffer, dch5@columbia.edu
Studies of the association between MRI-detected brain abnormalities and development among children with febrile seizures. Studies of the impact of acute management of severe brain injury on outcomes (in collaboration with the Brain Trauma Foundation). Studies of medical comorbidity associated with epilepsy.
Dr. Ruth Ottman, ro6@columbia.edu
Family and genetic studies of epilepsy. Identification of gene defects in relation to seizure/epilepsy phenotypes and seizure susceptibility. Linkage analysis and delineation of susceptibility genes for human epilepsy.
Dr. Melodie Winawer, mw211@columbia.edu
Family and genetic studies of epilepsy. Problems in phenotype definition.
Dr. Helen Scharfman, scharfman@helenhayeshosp.org
Electrophysiological and neuroanatomical studies in experimental models of epilepsy and epileptogenesis. Mechanisms of epileptic brain damage and functional consequences of brain lesions. Physiological effects of growth factors and neurotrophins. Neurogenesis as a consequence of seizures and its role in epileptogenesis.
Dr. Guy M. McKhann, II, gm317@columbia.edu
Roles of astrocytes in epilepsy; studies of glia-neuron interactions.
This group provides in-patient consultation services for patients with cognitive and behavioral disorders and staffs the Memory Disorders Clinic at the Psychiatric Institute. Residents are encouraged to elect rotations on this service. Research interests in behavioral disorders and dementia primarily focus on degenerative diseases such as Parkinson disease, Alzheimer disease, Huntington disease and stroke. Neurologic, psychiatric and neuropsychologic functions are assessed. Current projects include studies of dementia in Parkinson disease, use of brain imaging in dementia, clinical trials and epidemiology of Alzheimer disease and related disorders; natural history of HIV; cognitive performance in children with complex metabolic disorders. Aging and dementia rounds are held weekly at Columbia-Presbyterian Medical Center and monthly at Harlem Hospital Center. The research activities of the Division of Aging and Dementia are integrated closely with those of the Sergievsky Center, and all divisional faculty hold appointments in the Sergievsky Center.
Dr. Karen S. Marder, Director, ksm1@columbia.edu
Investigations of genetic influences in families of probands with early-onset compared to late-onset Parkinson disease. Multicenter investigation of risk factors for the development of dementia in HIV. Clinical trials of new therapeutic agents in Huntington disease. Longitudinal study of subjects at risk for developing Huntington disease.
Field work and clinical and basic research utilizing an extended kindred with Huntington disease living in Venezuela, including genotype/phenotype analyses. The Huntington Disease Center of Excellence provides experience in clinical care, psychotherapy and genetic counseling. Clinical trial of Coenzyme Q10 and remacemide in Huntington disease. Activities relating to the ethical, legal and social implications of the Human Genome Project.
Dr. Mark W. Albers, mwa28@columbia.edu
Laboratory research mapping the circuits that underlie odor discrimination in mice using genetic markers of olfactory neurons and genetic sensors of neuronal activation; cellular and molecular changes in these neurons induced by experience-dependent learning. Studies using transgenic models of Alzheimer disease to study how olfactory stimuli are processed.
Dr. Karen L. Bell, klb1@columbia.edu
Development of new clinical treatments for Alzheimer disease. Currently Conducting research for the prevention of Alzheimer disease in individuals with mild cognitive impairment. Other research interests include understanding barriers that minorities face in receiving clinical care for dementia and cognitive loss, and developing mechanisms to recruit minorities into clinical research.
Dr. Lucien Coté, lcote@sergievsky.cpmc.columbia.edu
Epidemiology and genetics of Parkinson disease. Studies of depression and dementia in Parkinson disease.
Dr. Laurence C. Honig, lh456@columbia.edu
Clinical studies of Alzheimer disease. Clinical-pathological correlations in Alzheimer disease and related dementias.
Dr. Jennifer Manly, jjm71@columbia.edu
Epidemiology and genetics of Parkinson disease. Studies of depression and dementia in Parkinson disease.
Dr. Richard Mayeux, rpm2@columbia.edu
see Sergievsky Center
Dr. Scott Small, sas68@columbia.edu
Correlations of memory and changes in the hippocampal formation using functional magnetic resonance imaging in normal aging and in Alzheimer disease.
Dr. Nancy S. Wexler, wexlern@pi.cpmc.columbia.edu
Genetic and field studies of Huntington disease in Maricaibo, Venezuela.
The Gertrude H. Sergievsky Center uses traditional and genetic epidemiologic approaches to the study of neurologic disorders. The areas of major interest include adverse reproductive outcomes, epilepsy and seizure disorders, degenerative diseases of the nervous system, developmental disorders of the nervous system, and neurological disorders of major public health impact. Allied disciplines in the health sciences include biostatistics, human genetics, neurology, obstetrics, pediatrics, physiology, psychiatry, psychology, and social sciences. The faculty of a federally funded training program in neuroepidemiology are located primarily within the Sergievsky Center.
Dr. Richard Mayeux, rpm2@columbia.edu
Director, G.H. Sergievsky Center and Co-Director, Taub Institute for Alzheimer Disease.
Dr. Steven M. Albert, sma10@Columbia.edu
Epidemiologic studies investigating the cognitive basis of functional competency of patients with HIV, Alzheimer disease and ALS. Ongoing studies of disease-related changes contributing to patient quality of life, nursing home placement, hospitalization and home care costs.
Dr. Jennie Kline, jkk3@columbia.edu
Epidemiology of spontaneous abortion; chromosomal disorders including trisomy; autism and other selected developmental disorders.
Dr. Ruth Ottman, ro6@columbia.edu
Neuroepidemiology and genetic studies of epilepsy, Parkinson disease and ALS.
Dr. Nicole Schupf, ns24@columbia.edu
Genetic epidemiology of Down syndrome and Alzheimer disease.
Dr. Zena Stein, zas2@columbia.edu
Epidemiology of mental retardation and developmental brain diseases.
Dr. W. Allen Hauser, wah1@columbia.edu
Associate Director (see Neuroepidemiology under the Comprehensive Epilepsy Center).
Dr. Karen S. Marder, ksm1@columbia.edu
(see Aging and Dementia)
Dr. Karen L. Bell, klb1@columbia.edu
(see Aging and Dementia)
Dr. Laurence C. Honig, lh456@columbia.edu
Dr. Elan D. Louis, edl2@columbia.edu
(see Movement Disorders)
Dr. Scott Small, sas68@columbia.edu
(see Aging and Dementia)
Dr. Yaakov Stern, Head, Cognitive Neuroscience, ys11@columbia.edu
Experimental and neuroimaging approaches to cognitive issues in normal aging and diseases of the aging brain (including Alzheimer, Parkinson and Huntington diseases). Current experimental cognitive studies include: source memory, working memory, priming, and the interplay between explicit recollection and familiarity in normal aging; basic timing mechanisms in normal aging and Parkinson disease; language and working memory in Alzheimer disease; and effects of literacy, education, ethnicity and acculturation on neuropsychological task performance in cognitive neuroimaging. Cognitive neuroimaging studies include: network changes in mediating recognition and working memory and cognitive reserve in normal aging and Alzheimer disease (H2 15O PET and fMRI); age priming in young adults and normal aging (ER-fMRI) executive function in normal aging and Huntington disease (fMRI), and effects of estrogen on recognition and source memory in elderly women (ERP).
Dr. Marc C. Patterson, Director, mcp73@columbia.edu
Pathophysiology of Niemann-Pick Disease, Type C. Therapeutic trials of Coenzyme Q10, and glucosylceramide synthase inhibition in Niemann-Pick, Type C. Diagnosis and management of congenital disorders of glycosylation. Studies of the neurobiological basis of autistic spectrum disorders.
Dr. Darryl C. De Vivo, dcd1@columbia.edu
Biochemical and molecular studies of inherited and acquired metabolic diseases that affect the developing nervous system and muscular system. Research focuses on defects of oxidative metabolism and the molecular basis of glucose transporter deficiency syndromes. Clinical trials in mitochondrial encephalomyopathies.
Dr. Claudia Chiriboga, cac3@columbia.edu
Studies of neurological, behavioral and psychological outcomes in children with intrauterine exposure to cocaine. Neuro-developmental outcomes of brain injuries associated with prematurity.
Dr. Linda Leary, ldl8@columbia.edu
Pediatric epilepsy and the role of epilepsy surgery in children. Studies of subtraction ictal SPECT and interictal PET scans in children with epilepsy being considered for surgery. Studies of the association of malformations of cortical development and intractable epilepsy. Age-dependent epileptic syndromes of childhood.
Dr. Arthur Mandel, amm28@columbia.edu
Disorders of cerebral energy failure, using functional magnetic resonance imaging.
Dr. Juan Pascual, jmp53@columbia.edu
Studies of ion channel structure, function and pharmacological modification in molecular excitability disorders, including genetic myopathies, neurotoxicity, epilepsy and arrhythmias.
Dr. Stephan A. Mayer, Director, sam14@columbia.edu
Dr. Christopher Commichau
Dr. Brian-Fred Fitzsimmons
Dr. Augusto Parra
Clinical trials and outcomes research related to intracerebral and aneurysmal subarachnoid hemorrhage. Clinical trials of hypothermia and hemicraniectomy for acute ischemic stroke. Quality of life and cognitive function after aneurismal subarachnoid hemorrhage. Other research interests include neurogenic cardiac arrhythmias, status epilepticus and end-of-life care.
Dr. Casilda Balmaceda, cb116@columbia.edu
Studies of primary brain tumors including gliomas, oligodendrogliomas, lymphomas and pineal tumors; leptomeningeal tumors; paraneoplastic syndromes. Multicenter clinical trials of new therapeutic agents.
Rose Lai, M.D., rl207@columbia.edu
The molecular epidemiology of brain tumors. Population-based studies to elucidate different genetic polymorphisms and their role in the pathogenesis of brain tumors, especially glioma. Using metabolic imaging techniques to identify molecular markers in brain tumors and predict responsiveness to treatment.
Steven Rosenfeld, M.D., Ph.D., sr2327@columbia.edu
Director, NYPH Brain Tumor Center
Novel ways of pharmacologically-blocking brain tumor growth and invasiveness by targeting the molecular motors that drive mitosis and cell motility.
Richard Anderson, M.D., rca24@columbia.edu
Clinical and basic science research investigating brain tumor immunology with special emphasis on pediatric brain tumors. Additional clinical research focuses on biomechanics of the pediatric spine and prenatal MRI.
Jeffrey Bruce, M.D., jnb2@columbia.edu
Studies into the molecular biology of brain tumors with an emphasis on potential targets for brain tumor therapy and clinical applications of laboratory-derived research. Clinical studies involving novel forms of brain tumor therapy.
E. Sander Connolly, M.D., esc5@columbia.edu
Vascular biology of ischemia and hemorrhagic stroke with a focus on the role of inflammatory cascades in tissue injury and recovery. Clinical outcome studies and trials of patients with ischemia and hemorrhagic stroke.
Saadi Ghatan, M.D., sg2160@columbia.edu
Programmed cell death during early neural development. Clinical research interests include studies in pediatric neurooncology and neurotrauma in children.
Robert R. Goodman, M.D., Ph.D., rrg2@columbia.edu
Clinical research studies on surgical treatment of intractable epilepsy, movement disorders and depression. Includes collaborative studies on investigational devices to improve the detection and treatment of epilepsy.
Michael G. Kaiser, M.D., mgk7@columbia.edu
Clinical and research interests focus on disorders of the spine and spinal cord. Research projects include clinical outcomes analysis, motion preservation, and computer simulation of the spine.
Guy M. McKhann, M.D., gm317@columbia.edu
Electrophysiological and morphological studies of astrocyte function in animal model and human epilepsy. Clinical investigation of brain organization of language and sensorimotor function.
Robert A. Solomon, M.D., ras5@columbia.edu
Clinical research on outcome of patients with cerebral arteriovenous malformations and aneurysms.
Christopher J. Winfree, M.D., cjw12@columbia.edu
My clinical research investigates the use of novel neurostimulation techniques to treat chronic pain. My basic science research explores the use of peripheral nerve transfers to treat spinal cord injury.
Laxmi V. Baxi, M.D., lvb1@columbia.edu
A range of research interests including genetics of pregnancy complications, genetic thrombophilia, diabetes mellitus and medical complications in pregnancy, habitual abortion and induction of labor.
Stephen Brown, M.D., sab8@columbia.edu
General area of investigation is human genetics and prenatal diagnosis. Currently the research focuses on the gene “Zic2” and its role in brain malformation.
Mary D’Alton, M.D., md511@columbia.edu
Leading researcher and expert clinician in all aspects of high-risk pregnancy with particular interest in prenatal diagnosis and multiple pregnancy.
Michel Ferin, M.D., mf8@columbia.edu
The neuroendocrine control of the menstrual cycle in the non-human primate, with emphasis on the role of GnRH in the normal cycle, on the interaction between the gonadal and adrenal endocrine axes and the physiopathology of stress-induced hypothalamic amenorrhea, and on the etiology of the polycystic ovary syndrome. Also, the role of angiogenic factors in folliculogenesis, uterine function and endometriosis.
Wylie C. Hembree III, M.D., wch2@columbia.edu
The role of testicular estrogens in sperm production and the treatment of male hypogonadism and male infertility.
Amalia Kelly, M.D., ack2@columbia.edu
Studies on the role of molecular variants of HCG in reproduction; early pregnancy loss. Ovarian aging and trisomy, menopause. Alternative medicine in women’s health problems.
Joyce Lustbader, Ph.D., jwl2@columbia.edu
Clinical and basic research studies focusing on the structure/function of hCG, endometriosis and the generation of novel new hormones.
Fergal D. Malone, M.D., fdm9@columbia.edu
Research on prenatal diagnosis, including obstetric ultrasonography, Down syndrome screening and invasive fetal testing. Research also focuses on problems with multiple gestations, prematurity prevention, critical care obstetrics and medical complications of pregnancy.
Julian Robinson, M.D.
Research interests primarily focus on prenatal diagnosis, multiple pregnancy, ultrasound scanning, fetal echocardiography, invasive diagnostic techniques and operative obstetrics.
Mark Sauer, M.D., mvs9@columbia.edu
Clinical and basic research in assisted reproduction (IVF and oocyte donation) and reproductive endocrinology.
Lynn L. Simpson, M.D., ls731@columbia.edu
Clinical studies on prenatal diagnosis, including the prenatal detection of fetal anomalies, congenital heart disease, chromosomal abnormalities and complications related to multiple gestations.
Michelle P. Warren, M.D., mpw1@columbia.edu
Clinical studies on the effects of hypoestrogenism on premenopausal osteoporosis in athletes and hypothalamic amenorrhea. Clinical studies with hormone replacement therapy, treatment of polycystic ovarian disease and menopause.
Carolyn Westhoff, M.D., clw3@columbia.edu
Epidemiologic studies concerning reproductive health. Also, contraceptive development and evaluation, prevention and screening.
Ming-Neng Yeh, M.D., my8@columbia.edu
Studies using ultrasound for detection of fetal anomalies, intra-uterine growth retardation and macrosomia as well as investigation of fetal microcirculation of the placenta.
Rando Allikmets, Ph.D., rla22@columbia.edu
Molecular genetics of macular and retinal diseases.
Gaetano Barile, M.D., grb17@columbia.edu
Studies of vascular biology in diabetic retinopathy and age-related macular degeneration.
Richard E. Braunstein, M.D., reb10@columbia.edu
Clinical studies in cataract surgery and refractive surgery.
Stanley Chang, M.D., sc434@columbia.edu
Studies of vitreoretinal diseases, complicated retinal detachments and ocular tamponades.
Michael Chiang, M.D., E.I., chiang@dbmi.columbia.edu
Bio-medical informatics, pediatric ophthalmology.
Lucian Del Priore, M.D., Ph.D., ld394@columbia.edu
Studies in retinal transplantation, macular degeneration.
James Dillon, M.D., jpd1@columbia.edu
Photobiology of the eye, structural changes in proteins, photosensitization.
Jorge Fischbarg, M.D., Ph.D., jf20@columbia.edu
Physiology of the cornea.
John T. Flynn, M.D., jtf38@columbia.edu
Pediatric ophthalmology, retinopathy of prematurity.
Peter Gouras, M.D., E.I., pg10@columbia.edu
Studies of retinal transplantation and gene therapy for retinal disorders.
Michael Kazim, M.D., E.I., mk48@columbia.edu
Research in orbital diseases.
Janet Sparrow, Ph.D., jrs88@columbia.edu
Studies of retinal cell biology, aging processes in the retina.
Larry Shapiro, Ph.D., lss8@columbia.edu
Structural and molecular biology of cadherins and diabetic retinopathy.
R. Theodore Smith, M.D., Ph.D., rts1@columbia.edu
Age-related macular degeneration, image enhancement techniques.
Melanie Sohocki, Ph.D., ms2241@columbia.edu
Molecular biology of Leber’s congenital amaurosis.
Stephen Trokel, M.D., trokel@columbia.edu
Laser development, optics and refractive surgery.
Basil Worgul, Ph.D., bvw1@columbia.edu
The effects of radiation on the eye.
Christopher S. Ahmad, M.D., csa4@columbia.edu
Ongoing clinical studies in sports medicine and shoulder surgery. Basic science studies are ongoing in knee and shoulder biomechanics, including topographic considerations for autologous osteochondral grafting and biomechanical analysis of double bundle PCL reconstructions.
Louis U. Bigliani, M.D., lub1@columbia.edu
Clinical studies in shoulder surgery including rotator cuff, instability and total joint replacements, fractures, arthroscopy and sports medicine are being pursued. The anatomy pathology and contact patterns of the subacromial space and rotator cuff are being studied as well as the mechanism of rotator cuff repair to bone.
Theodore A. Blaine, M.D., tb211@columbia.edu
Associate Director, Center for Shoulder, Elbow and Sports Medicine, Co-Director, Center for Orthopaedic Research, Principal Investigator, five-year multicenter outcome study of the Bigliani-Flatow total shoulder replacement prosthesis for osteoarthritis. Multiple ongoing clinical studies in shoulder and elbow arthritis, instability and tendon disorders. Current basic science interests include novel pharmacologic treatment strategies to prolong the life of joint replacement prostheses for osteoarthritis and rheumatoid arthritis, the biochemistry and molecular biology of fracture healing and the molecular pathophysiology of inflammatory conditions of the shoulder and elbow.
Catherine A. Compito, M.D., cac2004@columbia.edu
Specialization in shoulder surgery and sports medicine as well as care of fractures. Special interest/focus in women’s health.
Jeffrey A. Geller, M.D., jg2520@columbia.edu
Hip and knee replacement surgery, osteoporosis related fractures. Clinical research in outcomes of minimally invasive total hip and total knee replacement surgery, longevity of current hip and knee implants and pain management strategies in total joint replacement. Basic science research in biomechanics of fracture fixation around total joint implants.
Justin K. Greisberg, M.D., jkg2101@columbia.edu
Orthopedic foot and ankle surgery, and orthopedic trauma surgery. Clinical and basic research in adult acquired flat foot deformity. Basic science research continues in response of cartilage to blunt trauma, particularly apoptosis. Always looking for students to participate in short and long term projects.
Joshua E. Hyman, M.D. , jh736@columbia.edu
Pediatric Orthopedics. Clinical studies in treatment of pediatric fractures. Ongoing clinical studies include quality of life assessments for patients with cerebral palsy, club feet and fractures; assessment of spinal fusion rates following administration of ketorolac; and evaluation of pediatric ankle injuries.
Francis Y. Lee, M.D., CHONY-8N, fl127@columbia.edu
Director, Center for Orthopaedic Research. Chief, Tumor and Bone Disease; Pediatric Orthopaedics. Clinical studies in musculoskeletal tumors, metabolic bone disease and pediatric orthopedics. Basic science in bone tumors, osteoclast biology, molecular pathways of chondrocyte differentiation, molecular mechanisms of skeletal metastasis and molecular mechanisms of osteoblast and osteoclast interactions. Basic science studies in biomechanical and molecular aspects of fracture healing, limb lengthening, growth plate, bone remodeling and tissue engineering. Dr. Lee has been participating in P&S Student NIH Summer Fellowship Training Grant.
William N. Levine, M.D., wln1@columbia.edu
Director, Sports Medicine, Associate Director, Center for Shoulder, Elbow and Sports Medicine, Head Team Physician, Columbia University. Clinical and basic science studies in shoulder surgery, including instability, rotator cuff, total joint replacement, fractures and arthroscopy. Basic science studies in sports medicine, including ACL tears and various fixation methods. Clinical and basic science studies investigations are ongoing, including epidemiological studies of female athletes and the relationship to ACL tears.
William Macaulay, M.D., wm143@columbia.edu
Director, Center for Hip and Knee Replacement. Clinical multicenter outcome studies in primary and revision hip/knee surgery, post operative transfusion and hip fracture treatment. Additional outcome studies include long term survivorship analyses of primary and revision hip/knee prostheses as well asexploration into improved methods of post operative pain control and enhanced patient satisfaction following total knee replacement. Basic science research interests include the rational design of orthopedic implants and less invasive techniques, computer assisted surgery, the biology of periprosthetic bone resorption, thrombogenesis after total joint replacement, etiology and treatment of osteonecrosis.
Christopher B. Michelsen, M.D., cmb1@columbia.edu
Chief, Spine Service for Orthopaedic Surgery. Adult spine surgery with primary interest in the Failed Back Syndrome. Total hip and knee replacement and trauma surgery. Areas of interest are utilization of spinal instrumentation and implementation of computer-assisted joint replacement. Developing CUI in community-based orthopedic practice and treatment of failed back syndrome.
Michael T. Murray, M.D., mtm2114@columbia.edu
All areas of spinal disorders. Research areas include scoliosis, degenerative disc disease outcomes, research on spinal surgery patients. Minimally invasive spinal surgery, disc replacement and geriatric orthopaedic care. Students welcome for any short or long term research projects.
Ohannes Nercessian, M.D., oan1@columbia.edu
Dr. Nercessian’s particular areas of research include hip and knee surgery. The use of allograft in complex revision operations and in failed hip and knee surgery with significant bone loss. Research containing joint bearing surface material and doing surgery to minimize complications such as dislocation, infection and other risks ssociated with total joint replacement. Other areas of research include identifying factors that contribute to post-operative complications following total hip arthoplasty.
Melvin P. Rosenwasser, M.D., mpr2@columbia.edu
Cartilage research/trauma research. Experimental approaches are being developed to resurface cartilage defects using autogenous periosteal grafts and growth factors. Studies include research in the anatomy, function and stresses on the thumb basal joint with regard to its frequent progression to osteoarthritis. Research involving new approaches for tendon repair are underway. Clinical studies include comparisons of surgical techniques, implants and radiographic imaging modalities for orthopaedic trauma surgery. Development of new joint prostheses for hand and elbow reconstruction and the development of sophisticated computer models to guide and innovate new surgical approaches. Clinical outcome studies in fracture care of long bone injuries in the Trauma Training Center are ongoing. Students are welcome and many have completed NIH Summer Fellowships.
David P. Roye, Jr., M.D., dpr2@columbia.edu
Pediatric Orthopaedics. Elective is supervised for the entire division by Dr. Joshua Hyman. Clinical rotation includes Dr. Roye, Dr. Lee, Dr. Hyman and Dr. Vitale. Students are integrated into the extensive clinical research program of the division that emphasizes health related quality of life in children with orthopaedic problems. Current research topics include clubfoot, scoliosis, hip disease along with database research examining volume outcomes and access to care. Many research projects are collaborative with InCHOIR and the Mailman School of Public Health.
Robert J. Strauch, M.D., rjs8@columbia.edu
Clinical activities include hand and elbow surgery as well as microsurgery in adults and children. Basic science studies involve the thumb carpometacarpal joint anatomy, biomechanics and the pathophysiology of arthritis in that joint. Anatomical studies involve primarily the elbow, wrist and hand. Clinical studies include areas of concern in traumatic and reconstructive hand and elbow surgery.
Michael G. Vitale, M.D., M.P.H., mgv1@columbia.edu
Herbert Irving Assistant Professor of Orthopaedic Surgery. Pediatric Orthopaedics. Director, Pediatric section of International Center for Health Outcomes and Innovation Research. Clinical studies focusing on outcomes following scoliosis surgery, including minimally invasive techniques. Assessment of quality of life and cost-effectiveness outcomes in orthopaedics. Development of web-based on-line pediatric trauma registry. Evaluation of technologies to avert perioperative blood transfusions.
Mark Weidenbaum, M.D., mw8@columbia.edu
Adult and pediatric spine surgery. Areas of research include intrinsic material properties of intervertebral disc, spine fixation systems, fixed pelvic obliquity, and studies on spinal deformities. Clinical studies include assessment of spinal fusion techniques and minimally invasive spine procedures, as well as long term evaluation of spondylolisthesis and adult scoliosis.
Jeffrey M. Ahn, M.D., jma2@columbia.edu
Sleep disorder surgery. Facial plastic and reconstructive surgery and sinus surgery. Research area includes basic science research of facial nerve regeneration. Clinical research on sleep disorder and its treatment. Pathogenesis of rhinitis and sinusitis.
Jonathan E. Aviv, M.D., G.C.R.C., jea10@columbia.edu
Head and neck cancer surgery and reconstructive surgery of the head and neck. Clinical research includes innovative methods, techniques and devices that measure sensory discrimination in the pharynx and larynx.
Edward W. Chang, MD, DDS, ewc3@columbia.edu
Facial plastic and maxillofacial surgery. Sleep surgery and sinus surgery. Clinical research in the area of sleep disordered breathing, and facial plastic surgery.
Lanny Garth Close, M.D., lgc6@columbia.edu
Head and neck surgery. Endoscopic sinus surgery. Skull base surgery. Clinical research includes evaluation of head and neck cancer invasion and outcomes research in head and neck cancer.
Joseph Haddad, Jr., M.D., jh56@columbia.edu
Pediatric Otolaryngology. Lab projects include those on the pathogenesis of otitis media with effusion, examining the role of free radicals as contributors to inflammation. Clinical projects include antibiotic trials in acute media and otorrhea and epidemiologic studies of cleft lip and cleft palate in patients in Central America.
Shyam M. Khanna, Ph.D., smk3@columbia.edu
Basic research lab. Projects include: biophysics of hearing; cellular mechanics of the inner ear; confocal microscopy of inner ear in living animals; laser interferometric measurement of cellular vibration; neural coding in the auditory system.
Spiros Manolidis, M.D, FACS, FRCS, sm2397@columbia.edu
Basic science research: Robotic insertion of cochlear implant electrodes with minimal trauma to the cochlea for hearing preservation approaches (in conjunction with the mechanical engineering department) Robotic applications in Head & Neck cancer surgery. Clinical Research / Otology - Neurotology: Cochlear implant outcomes studies, Surgical technique and outcomes studies in advances chronic ear disease. Clinical Research / Head & Neck Surgery: combined treatment outcome studies in head & neck cancer, outcome studies on lateral skull base surgery for malignant tumors.
Thomas Murry, Ph.D., HP 8-812, tm2103@columbia.edu
Voice science including speech, voice and upper airway physiology. Acoustic, aerodynamic and sensory testing of vocal function and swallowing physiology. Voice research in the areas of new diagnostic technology, efficacy of treatment outcomes assessment and vocal fold physiology. Effects of respiration and vocal function.
Elizabeth Olson, Ph.D., ea92004@columbia.edu
Basic research lab. Projects include: biophysics of hearing; inner ear mechanics; intracochlear pressure measurements; confocal imaging of the inner and middle ear; laser interferometric measurements of inner and middle ear vibration.
Hector P. Rodriguez, M.D., hpr1@columbia.edu
Endoscopic sinus surgery, laser surgery for snoring and sleep apnea. Radio frequency waves (somnoplasty) for the treatment of nasal congestion and snoring. Rhinology and nasal allergy testing and immunotherapy.
Jaclyn Spitzer, Ph.D., jbs50@columbia.edu
Audiologic methods including hearing, balance and tinnitus evaluation, central auditory processing assessment, electrophysiologic measurement of processes involving auditory and vestibular pathways. Hearing research and rehabilitation studies utilizing cochlear implants, conventional and implantable hearing aids, bone-anchored hearing aids; evaluation of expanded criteria for these treatments; outcomes assessment of treatment efficacy.
Ian S. Storper, M.D., jss9@columbia.edu
Otology, neurotology, skull base surgery. Basic science research includes using the optical sectioning microscopy/laser interferometry to describe cochlear hair cell motion and using galvanic evoked potentials to measure the human vestibulospinal reflex. Clinical projects include the use of anticholinergic drugs to suppress vertigo, the use of antiviral drugs in the treatment of sudden-onset hearing loss and outcomes analysis of cranial nerve function in skull base surgery.
Gloria H. Su, Ph.D., gs2157@columbia.edu
Molecular oncology/cancer genetics. Basic research includes identifying tumor-suppressor genes important for head and neck tumorigenesis and studying their tumor-suppressive functions using transgenic and knock-out gene approaches. Transgenic and conditional knock-out mice and created for cancer modeling for the purposes of identifying novel markers, furthering our understandings of tumor biology, and developing early detections and chemopreventive therapeutics.
Asa Abeliovich, M.D., Ph.D., aa900@columbia.edu
The molecular mechanisms of neurodegeneration and the function and survival of dopamine receptors. We are studying the molecular bases of midbrain dopamine neuron function and survival. Midbrain dopamine neurons are thought to play a key role in learned and addictive behaviors, and degeneration of these neurons underlies Parkinson’s disease.
Ernest W. April, Ph.D., ewa1@columbia.edu
Muscle biophysics. Studies concerning the myofilament lattice, liquid crystals in biological systems, and malignant hyperthermia. Clinical anatomy.
Richard Baer, Ph.D., rb670@columbia.edu
BRCA1 and BARD1 function in breast cancer.
Jonathan M. Barasch, M.D., Ph.D., jmb4@columbia.edu
Epithelial cells of the kidney derive from mesenchymal cells and form the nephron, the functional unit of the organ. The conversion of mesenchyme into epithelia is controlled by the ureteric bud. Our work is dedicated to identifying signals from the ureteric bud that induce cell conversion, the cellular mechanisms that lead to the epithelial phenotype (de-novo), and the identification of the progenitors of the organ.
Jeannette Chloe Bulinski, Ph.D., jcb4@columbia.edu
Differentiation of cytoskeletal elements during morphogenesis. Expression and post-translational modifications of microtubule-associated proteins and tubulin functioning in mitosis and in skeletal and heart muscle differentiation.
Giorgio Cattoretti, M.D., gc87@columbia.edu
The pathogenesis of lymphoid neoplasia in humans and animal models.
Lorraine N. Clark, Ph.D., lc654@columbia.edu
Molecular genetics of Parkinson’s Disease.
Vivette D’Agati, M.D., vdd1@columbia.edu
Histologic, immunopathologic and ultrastructural studies of medical diseases of the kidney. Research projects include murine model of polycystic kidney disease, and clinical pathologic studies of HIV nephropathy, lupus, nephritis, focal segmental glomerulosclerosis and diabetic nephropathy.
Riccardo Dalla-Favera, M.D., rd10@columbia.edu
The general goal of this laboratory is to elucidate the pathogenesis of cancer. We focus on lymphoid malignancies and on the identification of genes that control B cell development and are altered in lymphoma. Altered genes, including oncogenes and tumor suppressor genes, are studied for their normal and pathologic functions using in vitro molecular biological assays as well as transgenic mouse models.
Thomas Diacovo, M.D., td2142@columbia.edu
Publications from research include, “Mechanics of transient platelet adhesion to von Willebrand factor under flow.” and “Adhesive mechanisms governing IPC recruitment into Lymph Nodes.”
Gilbert Di Paolo, Ph.D., dg2175@columbia.edu
Role of phosphoinositides in organelle trafficking, cytoskeletal dynamics and disease-related processes.
Fiona Doetsch, Ph.D., fkd2101@columbia.edu
Neural stem cells and their niche in the adult mammalian brain.
Andrew J. Dwork, M.D., ajd6@columbia.edu
The major focus of this laboratory is the study of neuroanatomic correlates of psychiatric disorders such as schizophrenia, mood disorders and suicide. In particular, we are interested in the causes of cognitive impairment among individuals suffering from these disorders. Of related interest are the neuroanatomic effects of external influences, such as chronic hospitalization, somatic treatments, and intellectual stimulation.
Phyllis L. Faust, M.D., Ph.D., plf3@columbia.edu
Investigation of human neuronal migration disorders. We have utilized gene targeting to develop a mouse model for the peroxisomal biogenesis disorder Zellweger syndrome. We are characterizing the central nervous system abnormalities that develop in these mice with morphologic, molecular and biochemical methods.
Daniel Fink, M.D., MPH, djf3@columbia.edu
Informatics in the clinical laboratory. Director of Core Laboratory, CUMC.
Paul B. Fisher, Ph.D., pbf1@columbia.edu
Molecular basis of carcinogenesis and cellular differentiation.
Greg A. Freyer, Ph.D., gaf1@columbia.edu
Molecular Biology and Biochemistry. Repair of UV damaged DNA and the regulation of this process.
Michael D. Gershon, M.D., mgd4@columbia.edu
Neurobiology, neuroanatomy and developmental neurobiology. A variety of studies concerning the enteric neuronal systems, from the migration of neural crest neuroblasts to the gut, to tissue interactions in development which lead to congenital megacolon.
James E. Goldman, M.D., Ph.D., jeg5@columbia.edu
Cellular and molecular studies of astrocyte and oligodendrocyte development and myelination; glial responses to pathological states, including demyelinating diseases; regulation and function of heat shock proteins in CNS glia; cytoskeletal proteins of neurons and glia; neurodegenerative diseases.
Ellen Greenebaum, M.D., eg39@columbia.edu
Cytopathology with special emphasis on Fine Needle Aspiration Biopsy, especially of thyroid, head and neck and ovarian cysts.
Lloyd A. Greene, Ph.D., lag3@columbia.edu
Cellular and molecular biology of neuronal development. Studies on the molecular mechanisms by which neurotrophic factors regulate neuronal differentiation and death. Investigations of the causes and prevention of neuronal cell death and degeneration.
Wei Gu, Ph.D., wg8@columbia.edu
Molecular mechanisms by which p53 mediates tumor suppression an