| 1767 | King’s College opens a medical school, the first in New York and only the second in the Colonies. |
| 1770 | King’s College awards first M.D. degree in the Colonies. |
| 1776 | The College closes due to the American Revolution. |
| 1784 | King’s reopens as Columbia College. |
| 1791 | Columbia revives the Medical School with Samuel Bard as Dean. |
| 1807 | The College of Physicians and Surgeons founded with a charter from the New York State Board of Regents; Dr. Bard becomes President in 1811. |
| 1813 | P&S moves to Barclay Street near City Hall. |
| 1814 | The Columbia Medical School, after years of decline, is merged into the College of Physicians and Surgeons. |
| 1837 | P&S moves to Crosby Street. |
| 1856 | P&S moves to the corner of Fourth Avenue (now Park Avenue South) and 23rd St. |
| 1860 | P&S severs its relationship with the Board of Regents and forges a nominal connection with Columbia; it still retains its independence. |
| 1884 | William Henry Vanderbilt gives P&S land on 59th Street between Ninth and Tenth Avenues and $300,000 to erect a new building. It is the largest donation to a medical school up to that time. |
| 1886 | Vanderbilt family members give funds to establish the Sloane Hospital for Women and the Vanderbilt Clinic. All three structures are finished in 1887. |
| 1891 | P&S completely merges with Columbia. |
| 1911 | Formal Agreement of Alliance between Columbia University and Presbyterian Hospital. |
| 1928 | Columbia-Presbyterian Medical Center, the world’s first medical center to combine complete facilities for patient care, medical education and research in a single complex, opens in Washington Heights on a site donated by Edward S. Harkness. Joining the Center are Babies Hospital (founded 1887), the Neurological Institute of New York (founded 1909) and the New York State Psychiatric Institute (founded 1896). |
| 1931 | Bard Hall opens. |
| 1933 | Harkness Institute of Ophthalmology opens. |
| 1950 | New York Orthopedic Hospital (est. 1866) moves to the Medical Center. |
| 1965 | Alumni Auditorium dedicated. |
| 1966 | William Black Medical Research Building dedicated. |
| 1976 | Hammer Health Sciences Center, housing the Augustus C. Long Health Sciences Library as well as classrooms and laboratories, opens. |
| 1989 | Milstein Hospital Building opens. |
| 1996 | First building of the Audubon Research Park opens. |
| 1998 | Russ Berrie Medical Science Pavilion completed. Construction completed on the new New York State Psychiatric Institute. |
| 2001 | 390 Ft. Washington Avenue Residence completed, October. |
| 2003 | Irving Cancer Research Center completed, fall. Morgan Stanley Children’s Hospital of NY- Presbyterian’s new bed tower completed, November 2003 and opens its doors. |
| 2005 | Irving Cancer Research Center dedicated. |
| 2006 | Glenda Garvey Teaching Academy inducts its first 13 faculty members. |
| 2007 | P&S Faculty Club renamed in honor of Donald F. Tapley, MD |