Richard Axel, M.D., ra27@columbia.edu
Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated.
Kathryn L. Calame, Ph.D., klc1@columbia.edu
Transcriptional regulatory cascades required for terminal differentiation of B lymphocytes and monocyte/macrophages; transformation of preB cells by the v-Abl tyrosine kinase.
Stephen P. Goff, Ph.D., goff@cancercenter.columbia.edu
Retroviral replication; tyrosine kinase oncogenes.
Max E. Gottesman, M.D., Ph.D., meg8@columbia.edu
Regulation of transcription termination in E. coli and bacteriophage; role of cAMP in cell cycle progression and signal transduction in eukaryotes; vitamin A metabolism in the mouse.
Eric Gouaux, Ph.D., jeg52@columbia.edu
Structure, function and chemistry of membrane proteins; X-ray crystallographic, molecular genetic and biochemical approaches.
Eric C. Greene, Ph.D., ecg2108@columbia.edu
Our lab utilizes total internal reflection fluourescence microscopy (TIRFM) to study the molecular machinery involved in the recombination and repair of damaged DNA. Using TIRFM to directly observe single reactions in real-time we can analyze the molecular mechanisms our cells use to fix damaged DNA with a degree of sensitivity not previously possible.
Iva Greenwald, Ph.D., isg4@columbia.edu
Cell-cell interactions, signal transduction, and cell fate choice; genetic and molecular studies of C. elegans development.
Wayne A. Hendrickson, Ph.D., wah2@columbia.edu
Structural biology of macromolecules; differentiation and computational methods.
David Hirsh, Ph.D., dih1@columbia.edu
Molecular genetics of endocytosis in C. elegans; role of cytokines in the mammalian inflammatory and immune responses.
Oliver Hobert, Ph.D., or38@columbia.edu
Genetic programs that control neural development in C. elegans.
Barry Honig, Ph.D., bh6@columbia.edu
Computational biology, bioinformatics, prediction of protein structure and function.
Thomas M. Jessell, Ph.D., tmj1@columbia.edu
Molecular mechanisms of neuronal differentiation, axon guidance and cell recognition in vertebrate development.
Eric Kandel, M.D., erk5@columbia.edu
Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates.
Arthur Karlin, Ph.D., ak12@columbia.edu
Molecular mechanisms of receptor function.
Richard S. Mann, Ph.D., rsm10@columbia.edu
Control of pattern formation by homeotic genes and their downstream targets in Drosophila.
Arthur G. Palmer, III, Ph.D., (Acting Chair) agp6@columbia.edu
Structure, function and dynamics of proteins; fluctuation in chemical and biological systems and nuclear magnetic resonance; and fluorescence spectroscopies.
Burkhard Rost, Ph.D., rost@columbia.edu
Bioinformatics. Goals: sequence analysis, prediction of protein structure and function. Means: statistics and artificial intelligence.
Lawrence Shapiro, Ph.D., lss8@columbia.edu
Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning.