John D. Allendorf, M.D., jda13@columbia.edu
Research involves innovative management of hepatic metastases.
Michael Argenziano, M.D., ma66@columbia.edu
Several trials of robotic cardiac surgery and surgical treatment of atrial fibrillation. Basic science and clinical laboratory focused atrial fibrillation, minimally invasive cardiac surgery, and cardiovascular physiology.
Marc S. Arkovitz, M.D., ma2161@columbia.edu
Genetics of lung development, pulmonary hypertension and congenital diaphragmatic hernia (CDH). We have developed collaborations with cardiology, genetics and neonatology.
Jeffrey Ascherman, M.D., jaa7@columbia.edu
Research involves studies of cranial volumes in children, sternal wounds, and different techniques of breast reconstruction following mastectomy.
Marc Bessler, M.D., mb28@columbia.edu
Principal investigator of LAP BAND® clinical trial, targeted toward patients who are not heavy enough for weight loss surgery based on standard criteria, but are suffering from medical problems and quality of life issues.
Harold Brem, M.D., hb2133@columbia.edu
Improving outcomes for patients with leg ulcers, pressure ulcers and other non healing wounds. Mission is to decrease amputations and severe pressure ulcers. Focus is on integrated care to test the hypothesis that the electronic medical record can reduce morbidity and mortality in the elderly, disabled and those with diabetes.
Robert S. Brown Jr., M.D., M.P.H., rd464@columbia.edu
Principal investigator of Viser I trial, a study comparing the standard treatment for chronic Hepatitis C to a new therapy.
Jonathan M. Chen, M.D., jmc23@columbia.edu
Studies related to surgery for congenital heart disease, transplantation and mechanical ventricular assistance. Alternative anticoagulants for cardiopulmonary bypass and cardiac physiology in animal models of congenital heart disease.
Robert A. Cowles, M.D., rc2114@columbia.edu
Clinical and Basic Science aspects of short gut syndrome. Collaboration developed with Michael Gershon (Anatomy) to study the remodeling of the enteric nervous system after bowel resection.
Peter L. Faries, M.D., pf2105@columbia.edu
Carotid Artery Angioplasty and Stenting clinical trial, a minimally invasive alternative to stroke prevention.
Dennis L. Fowler, M.D., dlf91@columbia.edu
Investigation of the different tissue ingrowth into different mesh hernia prostheses in animals. Clinical investigation of the impact on the outcome of laparoscopic surgical procedures when performed by residents after training on a virtual simulator.
Annetine Gelijns, Ph.D., acp10@columbia.edu
Directs data coordinating centers for clinical trials in surgery.
Mark E. Ginsburg, M.D., meg18@columbia.edu
Co-investigator of Endobrochial Valve for Emphysema Palliation Trial (VENT), a minimally invasive alternative to lung volume reduction surgery (LVRS).
Robert T. Grant, M.D., M.S., rg424@columbia.edu
1) Post-approval study of silicone gel breast implants, 2) the on-going study of silicone gel implants in patients who received these devices for reconstructive reasons, 3) musculoskeletal complaints, 3) physical fitness and nutrition habits of surgical trainees and Attending surgeons, and 4) the expanded role for electroceutical devices in post-op wound healing and pain control.
Mark Hardy, M.D., mah1@columbia.edu
1) induction of transplantation tolerance both in vitro with human cells and in vivo in various animal models; 2) Clinical islet transplantation and development of new methods of pancreatic islet isolation, placement, and PET imagining in experimental animal models; 3) Conduct of clinical trials with new immunosuppressive agents in renal transplant recipients and use of other agents in wound healing.
Kevan C. Herold, M.D., kh318@columbia.edu
Clinical research tests cellular and immune therapies against type I diabetes. Co-investigator of islet cell transplantation clinical trial.
WB Inabnet, M.D., FACS, wbi2102@columbia.edu
1) Primary hyperparathyroidism: Non-classical manifestations. 2) Relationship between hyperparathyroidism and cardiovascular disease, 3) effect of gastric restriction and malabsorption on gut petides and diabetes in a rat model.
Silviu Itescu, M.D., si5@columbia.edu
Two clinical trials testing the therapeutic potential of adult stem cells in human patients with heart disease.
Kathie-Ann Joseph, M.D., kpr2@columbia.edu
Synergism of RAGE (Receptor for Advanced Glycation End products, a cell surface receptor molecule) with chemotherapy and identifying a single antagonist of RAGE for development as a new therapeutic agent in breast cancer.
Jessica J. Kandel, M.D., jjk47@columbia.edu
Angiogenesis in pediatric solid tumor models (Wilms tumor, neuroblastoma, and hepatoblastoma), centering on the role of vascular endothelial growth factor and the response to its inhibition, in terms of altered expression of proapoptotic and tumor suppressor genes by malignant cells and vascular remodeling/genetic changes in endothelial cells.
Howard L. Kaufman, M.D., hlk2003@columbia.edu
Application of immunotherapy, or tumor vaccines, to treat metastatic cancer. Principal investigator of a clinical trial which tests two particular tumor vaccines against metastatic melanoma.
K. Craig Kent, M.D., kckent@mail.med.cornell.edu
Outcomes in vascular disease using decision analysis models and evaluation of large data sets.
James A. Lee, M.D., jal74@columbia.edu
Research into a novel medical education paradigm (COACH) using technology to enhance training. Research into various aspects of endocrine disease.
James F. McKinsey, M.D., jfm2111@columbia.edu
Thoracic Aortic Stent-graft trial, which tests a minimally invasive treatment for patients with thoracic aortic aneurysms.
Nicholas Morrissey, M.D., njm2106@columbia.edu
Clinical research analyzing the importance of race and ethnicity on the incidence, treatment, and outcome of peripheral vascular disease. The project focuses on Hispanic and African American patients and their rates of important vascular diseases. We also will be looking at access to healthcare issues and results of treatment. We will be developing a model to assess the reasons for failure of synthetic arteriovenous grafts and arterial bypass grafts in order to determine methods for preventing failure of these grafts.
Ralph Mosca, M.D., rm891@columbia.edu
1) SVR trial (Single Ventricle Resconstruction: Sano vs BT shunt in the Repair of Hypoplastic Left Heart Syndrome, 2) ACE inhibition in Single Ventricle Lesions, 3) Multi-site Pacing to Improve Ventricular Function Following Repair of Tetralogy of Fallot, 4) Clinical Application of the “Physiologic Pediatric Pulsatile Pump.
Yoshifumi Naka, M.D., Ph.D., yn33@columbia.edu
Clinical studies of LVAD effects. Basic studies of vein graft disease. Basic studies of arterial remodeling following injury.
Roman Nowygrod, M.D., rn5@columbia.edu
Outcomes research on medical errors tracking and reporting; quality of life after open vs. endovascular aneurysm repair; systemic coagulation changes after prosthetic graft implants; prospective study of renal dysfunction after contrast infusion in patients undergoing peripheral arterial endovascular therapies.
Mehmet C. Oz, M.D., mco2@columbia.edu
Clinical studies of effects of cardiopulmonary bypass. Innovative methods of mitral repair.
Lloyd E. Ratner, M.D., lr2182@columbia.edu
1) innovative strategies to increase/improve access to organ transplantation, 2) application of minimally invasive and laparoscopic surgical techniques to transplantation, 3) abrogation of humoral immune responses, 4) study of near miss phenomena in regards to surgical morbidity and mortality, and e) ethical and physiologic concerns in the management of deceased solid organ donors.
John F. Renz, M.D., Ph.D., jfr2103@columbia.edu
Research in the development of hepatocellular carcinoma, investigations into expanded donor criteria allografts and experimental therapies involving liver and intestinal transplantation in adults and children.
Christine Rohde, M.D., chr2111@columbia.edu
Efficacy of pulsed magnetic fields in reducing pain and wound healing complications in breast reduction patients, the molecular effects of mechanical stress on wound healing, additional research in rat models on pulsed magnetic fields, and the long-term follow-up of silicone breast implant patients.
Eric A. Rose, M.D., ear3@columbia.edu
Clinical trial focused on patients with end-stage heart failure who have a left ventricular assist device (LVAD) implanted; adult stem cells will be evaluated for their ability to help repair or regenerate the native hearts of these patients, so that the LVAD might be removed.
Benjamin Samstein, M.D., bs212@columbia.edu
Mechanisms of antibody mediated rejection and accommodation. We use genetically modified animals in transplant models of kidney and cardiac transplantation to understand B cell immunology. For more information see http://www.columbiasurgery.org/res/immunology/index.html
Ann Marie Schmidt, M.D., ams11@columbia.edu
Research focused on a multiligand receptor called Receptor for AGE or RAGE. Studies to access the impact of RAGE on diabetic complications, proinflammatory pathways, tumor growth and invasion, and degenerative orders of the central nervous system are being performed.
Henry M. Spotnitz, M.D., hms2@columbia.edu
Intraoperative two-dimensional echocardiography, intraventricular pressure, and aortic flow probes to define effects of surgery on cardiac function. Original methods for detecting changes in LV compliance, systolic function, and mass, utilizing the loading and unloading effects of cardiopulmonary bypass, effects of edema on ventricular function and geometry, structure-function relations using electron and light microscopy.
Charles J. H. Stolar, M.D., cjs3@columbia.edu
Research involves studies of Pectus Excavatum.
Bret Taback, M.D., bt2160@columbia.edu
Novel approaches to detect micrometastasis and tumor genetic alterations. Principal investigator of a tissue procurement protocol for breast and melanoma.
Richard L. Whelan, M.D., rlw3@columbia.edu
Clinical investigation of Cytokine Granulocyte-Macrophage Colony Stimulating Factor
(GM-CSF), a drug which aims to reduce tumor recurrences in colorectal cancer patients.
June Wu, M.D., jw92@columbia.edu
Investigations are being conducted in mechanisms of delayed wound healing and diabetes and other conditions, and the efficacy of physical and chemical devices to improve wound healing. Other current studies examine normal and aberrant vasculogenesis in vascular tumors and malformations.
Jeffrey Zitsman, M.D., jlz2@columbia.edu
Principal investigator of LAP BAND® clinical trial in adolescents to measure efficacy and safety of device in teens who have failed to lose weight through diet, exercise, and medication. Carotid Artery Angioplasty and Stenting clinical trial, a minimally invasive alternative to stroke prevention.